| UniProt Protein Function: | NMDAR2D: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: cell junction; intracellular; N-methyl-D-aspartate selective glutamate receptor complex; plasma membrane; postsynaptic membrane Molecular Function:extracellular-glutamate-gated ion channel activity; N-methyl-D-aspartate selective glutamate receptor activity; protein binding Biological Process: activation of MAPKK activity; adult locomotory behavior; axon guidance; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; ionotropic glutamate receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; Ras protein signal transduction; regulation of sensory perception of pain; signal transduction; small GTPase mediated signal transduction; startle response; synaptic transmission; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010] |
| UniProt Code: | O15399 |
| NCBI GenInfo Identifier: | 229462910 |
| NCBI Gene ID: | 2906 |
| NCBI Accession: | O15399.2 |
| UniProt Secondary Accession: | O15399,Q03391, Q62645, |
| UniProt Related Accession: | O15399 |
| Molecular Weight: | 143,752 Da |
| NCBI Full Name: | Glutamate receptor ionotropic, NMDA 2D |
| NCBI Synonym Full Names: | glutamate ionotropic receptor NMDA type subunit 2D |
| NCBI Official Symbol: | GRIN2D |
| NCBI Official Synonym Symbols: | EB11; NR2D; GluN2D; NMDAR2D |
| NCBI Protein Information: | glutamate receptor ionotropic, NMDA 2D |
| UniProt Protein Name: | Glutamate receptor ionotropic, NMDA 2D |
| UniProt Synonym Protein Names: | EB11; Glutamate [NMDA] receptor subunit epsilon-4; N-methyl D-aspartate receptor subtype 2D; NMDAR2D; NR2D |
| Protein Family: | Glutamate receptor ionotropic |
| UniProt Gene Name: | GRIN2D |
| UniProt Entry Name: | NMDE4_HUMAN |
