Anti-GLYCTK Antibody (CAB7852)
- SKU:
- CAB7852
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GLYCTK Antibody |
| 抗体コード: | CAB7852 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 284-523 of human GLYCTK (NP_660305.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse liver, Mouse kidney, Rat liver, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 284-523 of human GLYCTK (NP_660305.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VKTV LSRA DSDP HGPH TCGH VLNV IIGS NVLA LAEA QRQA EALG YQAV VLSA AMQG DVKS MAQF YGLL AHVA RTRL TPSM AGAS VEED AQLH ELAA ELQI PDLQ LEEA LETM AWGR GPVC LLAG GEPT VQLQ GSGR GGRN QELA LRVG AELR RWPL GPID VLFL SGGT DGQD GPTE AAGA WVTP ELAS QAAA EGLD IATF LAHN DSHT FFCC LQGG AHLL HTGM TGTN VMDT HLLF LRPR |
| 遺伝子ID: | 132158 |
| Uniprot: | Q8IVS8 |
| セルラーロケーション: | Cytoplasm, Cytoplasm, Mitochondrion |
| 計算された分子量: | 19kDa/22kDa/25kDa/38kDa/48kDa/55kDa |
| 観察された分子量: | 55kDa |
| 同義語: | GLYCTK, HBEBP2, HBEBP4, HBeAgBP4A |
| バックグラウンド: | This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. |
| UniProt Protein Function: | GLYCTK: Defects in GLYCTK are the cause of D-glyceric aciduria (D-GA). D-GA is a rare metabolic disease characterized by chronic metabolic acidosis and a highly variable clinical phenotype. Clinical features range from an encephalopathic presentation with seizures, microcephaly, severe mental retardation and early death, to milder manifestations with only speech delay or even normal development. Belongs to the glycerate kinase type-2 family. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 2.7.1.31; Lipid Metabolism - glycerolipid; Amino Acid Metabolism - glycine, serine and threonine; Kinase, other Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: cytoplasm; cytosol Molecular Function:glycerate kinase activity; protein binding Biological Process: protein amino acid phosphorylation Disease: D-glyceric Aciduria |
| NCBI Summary: | This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009] |
| UniProt Code: | Q8IVS8 |
| NCBI GenInfo Identifier: | 74728080 |
| NCBI Gene ID: | 132158 |
| NCBI Accession: | Q8IVS8.1 |
| UniProt Secondary Accession: | Q8IVS8,Q0P630, Q2EZ43, Q6Y2K6, Q7Z6G5, Q86YR8, Q8TED2 Q8WTY2, |
| UniProt Related Accession: | Q8IVS8 |
| Molecular Weight: | 22,027 Da |
| NCBI Full Name: | Glycerate kinase |
| NCBI Synonym Full Names: | glycerate kinase |
| NCBI Official Symbol: | GLYCTK |
| NCBI Official Synonym Symbols: | HBEBP2; HBEBP4; HBeAgBP4A |
| NCBI Protein Information: | glycerate kinase |
| UniProt Protein Name: | Glycerate kinase |
| UniProt Synonym Protein Names: | HBeAg-binding protein 4 |
| UniProt Gene Name: | GLYCTK |
| UniProt Entry Name: | GLCTK_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GLYCTK antibody (CAB7852) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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