Anti-GDF15 Antibody (RACO0431)
- SKU:
- RACO0431
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 商品名: | GDF15 Antibody |
| Product SKU: | RACO0431 |
| サイズ: | 50ul |
| 宿主種: | Homo sapiens (Human) |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | IHC:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | A synthesized peptide derived from human GDF15 |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | cytoplasm, extracellular exosome, extracellular region, extracellular space, nucleus, cytokine activity, transforming growth factor beta receptor binding, BMP signaling pathway, cell development, cell-cell signaling |
| シノニム: | Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor), GDF15, MIC1 PDF PLAB PTGFB |
 | IHC image of RACO0431 diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| UniProt Protein Function: | GDF15: disulfide-linked. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cytokine Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: extracellular region; extracellular space Molecular Function:transforming growth factor beta receptor binding Biological Process: cell development; cell-cell signaling; regulation of apoptosis; regulation of MAPKKK cascade; signal transduction; transforming growth factor beta receptor signaling pathway |
| NCBI Summary: | The protein encoded by this gene belongs to the transforming growth factor-beta (TGF-beta) family. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress reponse program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q99988 |
| NCBI GenInfo Identifier: | 313104195 |
| NCBI Gene ID: | 9518 |
| NCBI Accession: | Q99988.3 |
| UniProt Secondary Accession: | Q99988,O14629, P78360, Q9BWA0, Q9NRT0, |
| UniProt Related Accession: | Q99988 |
| Molecular Weight: | |
| NCBI Full Name: | Growth/differentiation factor 15 |
| NCBI Synonym Full Names: | growth differentiation factor 15 |
| NCBI Official Symbol: | GDF15 |
| NCBI Official Synonym Symbols: | PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15 |
| NCBI Protein Information: | growth/differentiation factor 15 |
| UniProt Protein Name: | Growth/differentiation factor 15 |
| UniProt Synonym Protein Names: | Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor |
| Protein Family: | Growth/differentiation factor |
| UniProt Gene Name: | GDF15 |
| UniProt Entry Name: | GDF15_HUMAN |