Anti-GDF10 Antibody (CAB10560)
- SKU:
- CAB10560
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GDF10 Antibody |
| 抗体コード: | CAB10560 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 369-478 of human GDF10 (NP_004953.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | BxPC-3, U-251MG, HeLa, Mouse brain, Mouse liver, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 369-478 of human GDF10 (NP_004953.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QWDE PRVC SRRY LKVD FADI GWNE WIIS PKSF DAYY CAGA CEFP MPKI VRPS NHAT IQSI VRAV GIIP GIPE PCCV PDKM NSLG VLFL DENR NVVL KVYP NMSV DTCA CR |
| 遺伝子ID: | 2662 |
| Uniprot: | P55107 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 53kDa |
| 観察された分子量: | 53kDa |
| 同義語: | GDF10, BIP, BMP-3b, BMP3B |
| バックグラウンド: | The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis. |
| UniProt Protein Function: | GDF10: is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that plays a role in skeletal morphogenesis. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 10q11.22 Cellular Component: extracellular space Molecular Function:cytokine activity; transforming growth factor beta receptor binding Biological Process: BMP signaling pathway; cell development; negative regulation of osteoblast differentiation; regulation of apoptosis; regulation of MAPKKK cascade; skeletal development; transforming growth factor beta receptor signaling pathway |
| NCBI Summary: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016] |
| UniProt Code: | P55107 |
| NCBI GenInfo Identifier: | 1705471 |
| NCBI Gene ID: | 2662 |
| NCBI Accession: | P55107.1 |
| UniProt Secondary Accession: | P55107,Q5VSQ8, Q9UCX6, |
| UniProt Related Accession: | P55107 |
| Molecular Weight: | 53kDa |
| NCBI Full Name: | Growth/differentiation factor 10 |
| NCBI Synonym Full Names: | growth differentiation factor 10 |
| NCBI Official Symbol: | GDF10 |
| NCBI Official Synonym Symbols: | BIP; BMP3B; BMP-3b |
| NCBI Protein Information: | growth/differentiation factor 10 |
| UniProt Protein Name: | Growth/differentiation factor 10 |
| UniProt Synonym Protein Names: | Bone morphogenetic protein 3B; BMP-3B; Bone-inducing protein; BIP |
| Protein Family: | Growth/differentiation factor |
| UniProt Gene Name: | GDF10 |
 | Western blot analysis of extracts of various cell lines, using GDF10 antibody (CAB10560) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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