Anti-GABRA5 Antibody (RACO0485)
- SKU:
- RACO0485
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 商品名: | GABRA5 Antibody |
| Product SKU: | RACO0485 |
| サイズ: | 50ul |
| 宿主種: | Homo sapiens (Human) |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | WB:1:500-1:5000, IHC:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | A synthesized peptide derived from human GABA A Receptor alpha 5 |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
| シノニム: | Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5), GABRA5 |
 | IHC image of RACO0485 diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
 | Western Blot. Positive WB detected in Ntera-2 whole cell lysate HEK293 whole cell lysate All lanes GABA A Receptor alpha 5 antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 53 kDa. Observed band size: 70 kDa. |
| UniProt Protein Function: | GABRA5: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub-subfamily. |
| UniProt Protein Details: | Protein type:Transporter; Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q12 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:GABA-A receptor activity; receptor activity; transporter activity Biological Process: positive regulation of defense response to virus by host; signal transduction; transport |
| NCBI Summary: | GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P31644 |
| NCBI GenInfo Identifier: | 15030265 |
| NCBI Gene ID: | 2558 |
| NCBI Accession: | BC011403 |
| UniProt Secondary Accession: | P31644,Q14DC2, Q53XL6, Q9NYT3, Q9NYT4, Q9NYT5, A8K338 |
| UniProt Related Accession: | P31644,AAB22608 |
| Molecular Weight: | 52,146 Da |
| NCBI Full Name: | Homo sapiens cDNA clone IMAGE:3868411, **** WARNING: chimeric clone **** |
| NCBI Synonym Full Names: | gamma-aminobutyric acid type A receptor alpha5 subunit |
| NCBI Official Symbol: | GABRA5 |
| NCBI Protein Information: | gamma-aminobutyric acid receptor subunit alpha-5 |
| UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit alpha-5 |
| UniProt Synonym Protein Names: | GABA(A) receptor subunit alpha-5 |
| Protein Family: | Gamma-aminobutyric acid receptor |
| UniProt Gene Name: | GABRA5 |
| UniProt Entry Name: | GBRA5_HUMAN |