Anti-GAB2 Antibody (CAB13066)
- SKU:
- CAB13066
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-GAB2 Antibody |
| 抗体コード: | CAB13066 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 377-676 of human GAB2 (NP_536739.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HeLa, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 377-676 of human GAB2 (NP_536739.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ENSR SVAA TIPR RNTL PAMD NSRL HRAS SCET YEYP QRGG ESAG RSAE SMSD GVGS FLPG KMIV GRSD STNS EDNY VPMN PGSS TLLA MERA GDNS QSVY IPMS PGAH HFDS LGYP STTL PVHR GPSR GSEI QPPP VNRN LKPD RKAK PTPL DLRN NTVI DELP FKSP ITKS WSRA NHTF NSSS SQYC RPIS TQSI TSTD SGDS EENY VPMQ NPVS ASPV PSGT NSPA PKKS TGSV DYLA LDFQ PSSP SPHR KPST SSVT SDEK VDYV QVDK EKTQ ALQN TMQE WTDV RQSS EPSK GAKL |
| 遺伝子ID: | 9846 |
| Uniprot: | Q9UQC2 |
| セルラーロケーション: | Cell membrane, Cytoplasm |
| 計算された分子量: | 69kDa/74kDa |
| 観察された分子量: | 74kDa |
| 同義語: | GAB2 |
| バックグラウンド: | This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | GAB2: an adaptor protein of the GRB2-associated binding protein family. Plays important roles in regulating the growth, differentiation, and function of many hematopoietic cell types. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 11q14.1 Cellular Component: cytoplasm; cytosol; plasma membrane Molecular Function:phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; transmembrane receptor protein tyrosine kinase adaptor protein activity Biological Process: osteoclast differentiation; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of mast cell degranulation |
| NCBI Summary: | This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009] |
| UniProt Code: | Q9UQC2 |
| NCBI GenInfo Identifier: | 46396035 |
| NCBI Gene ID: | 9846 |
| NCBI Accession: | Q9UQC2.1 |
| UniProt Secondary Accession: | Q9UQC2,O60317, A2RRM2, A6NEW9, A7MD36, |
| UniProt Related Accession: | Q9UQC2 |
| Molecular Weight: | 69,968 Da |
| NCBI Full Name: | GRB2-associated-binding protein 2 |
| NCBI Synonym Full Names: | GRB2 associated binding protein 2 |
| NCBI Official Symbol: | GAB2 |
| NCBI Protein Information: | GRB2-associated-binding protein 2 |
| UniProt Protein Name: | GRB2-associated-binding protein 2 |
| UniProt Synonym Protein Names: | GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100 |
| Protein Family: | GRB2-associated-binding protein |
| UniProt Gene Name: | GAB2 |
| UniProt Entry Name: | GAB2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GAB2 antibody (CAB13066) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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