Anti-FUCA1 Antibody (CAB14533)
- SKU:
- CAB14533
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-FUCA1 Antibody |
| 抗体コード: | CAB14533 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 253-395 of human FUCA1 (NP_000138.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse kidney, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 253-395 of human FUCA1 (NP_000138.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SPVK DEVV VNDR WGQN CSCH HGGY YNCE DKFK PQSL PDHK WEMC TSID KFSW GYRR DMAL SDVT EESE IISE LVQT VSLG GNYL LNIG PTKD GLIV PIFQ ERLL AVGK WLSI NGEA IYAS KPWR VQWE KNTT SVWY TSKG SAV |
| 遺伝子ID: | 2517 |
| Uniprot: | P04066 |
| セルラーロケーション: | Lysosome |
| 計算された分子量: | 53kDa |
| 観察された分子量: | 53kDa |
| 同義語: | FUCA1, FUCA |
| バックグラウンド: | The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2. |
| UniProt Protein Function: | FUCA1: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins. Defects in FUCA1 are the cause of fucosidosis (FUCA1D). FUCA1D is an autosomal recessive lysosomal storage disease characterized by accumulation of fucose-containing glycolipids and glycoproteins in various tissues. Clinical signs include facial dysmorphism, dysostosis multiplex, moderate hepatomegaly, severe intellectual deficit, deafness, and according to age, angiokeratomas. Belongs to the glycosyl hydrolase 29 family. |
| UniProt Protein Details: | Protein type:Glycan Metabolism - other glycan degradation; EC 3.2.1.51; Hydrolase Chromosomal Location of Human Ortholog: 1p34 Cellular Component: cytoplasm; lysosomal lumen Molecular Function:alpha-L-fucosidase activity Biological Process: fucose metabolic process; glycoside catabolic process Disease: Fucosidosis |
| NCBI Summary: | The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009] |
| UniProt Code: | P04066 |
| NCBI GenInfo Identifier: | 156631012 |
| NCBI Gene ID: | 2517 |
| NCBI Accession: | P04066.4 |
| UniProt Secondary Accession: | P04066,Q14334, Q14335, Q3LID0, Q8NAC2, B2RBG3, |
| UniProt Related Accession: | P04066 |
| Molecular Weight: | 53,689 Da |
| NCBI Full Name: | Tissue alpha-L-fucosidase |
| NCBI Synonym Full Names: | fucosidase, alpha-L- 1, tissue |
| NCBI Official Symbol: | FUCA1 |
| NCBI Official Synonym Symbols: | FUCA |
| NCBI Protein Information: | tissue alpha-L-fucosidase |
| UniProt Protein Name: | Tissue alpha-L-fucosidase |
| UniProt Synonym Protein Names: | Alpha-L-fucosidase I; Alpha-L-fucoside fucohydrolase 1; Alpha-L-fucosidase 1 |
| Protein Family: | Tissue alpha-L-fucosidase |
| UniProt Gene Name: | FUCA1 |
| UniProt Entry Name: | FUCO_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FUCA1 antibody (CAB14533) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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