Anti-FOXO4 Antibody (RACO0153)
- SKU:
- RACO0153
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Conjugation:
- Unconjugated
Description
| 商品名: | FOXO4 Antibody |
| Product SKU: | RACO0153 |
| サイズ: | 50ul |
| 宿主種: | Human |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | A synthesized peptide derived from human FOXO4 |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. |
| シノニム: | Forkhead box protein O4, Fork head domain transcription factor AFX1, FOXO4, AFX, AFX1, MLLT7 |
| UniProt Protein Function: | FOXO4: transcription factor AFX1 containing 1 fork-head domain. May play a role in the insulin signaling pathway. Involved in acute leukemias by a chromosomal translocation t(X;11)(q13;q23) that involves MLLT7 and MLL/HRX. The result is a rogue activator protein. Two splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Oncoprotein; Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: Xq13.1 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:beta-catenin binding; DNA binding; enzyme binding; identical protein binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding Biological Process: cell cycle arrest; insulin receptor signaling pathway; negative regulation of angiogenesis; negative regulation of cell proliferation; negative regulation of smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; stem cell differentiation; transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] |
| UniProt Code: | P98177 |
| NCBI GenInfo Identifier: | 110825720 |
| NCBI Gene ID: | 4303 |
| NCBI Accession: | P98177.5 |
| UniProt Secondary Accession: | P98177,O43821, Q13720, Q3KPF1, Q8TDK9, B7WPJ7, |
| UniProt Related Accession: | P98177 |
| Molecular Weight: | 47,941 Da |
| NCBI Full Name: | Forkhead box protein O4 |
| NCBI Synonym Full Names: | forkhead box O4 |
| NCBI Official Symbol: | FOXO4 |
| NCBI Official Synonym Symbols: | AFX; AFX1; MLLT7 |
| NCBI Protein Information: | forkhead box protein O4 |
| UniProt Protein Name: | Forkhead box protein O4 |
| UniProt Synonym Protein Names: | Fork head domain transcription factor AFX1 |
| Protein Family: | Forkhead box protein |
| UniProt Gene Name: | FOXO4 |
| UniProt Entry Name: | FOXO4_HUMAN |