| UniProt Protein Function: | Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis. |
| NCBI Summary: | This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] |
| UniProt Code: | O43155 |
| NCBI GenInfo Identifier: | 1071034772 |
| NCBI Gene ID: | 23768 |
| NCBI Accession: | NP_001333072.1 |
| UniProt Secondary Accession: | O43155,A0AV84, B7ZLP3, |
| UniProt Related Accession: | O43155 |
| Molecular Weight: | Molecular Mass: 57.3kDaActual Protein Molecular Mass: 78kDa |
| NCBI Full Name: | leucine-rich repeat transmembrane protein FLRT2 |
| NCBI Synonym Full Names: | fibronectin leucine rich transmembrane protein 2 |
| NCBI Official Symbol: | FLRT2 |
| NCBI Protein Information: | leucine-rich repeat transmembrane protein FLRT2 |
| UniProt Protein Name: | Leucine-rich repeat transmembrane protein FLRT2 |
| UniProt Synonym Protein Names: | Fibronectin-like domain-containing leucine-rich transmembrane protein 2 |
| Protein Family: | Leucine-rich repeat transmembrane protein |
| UniProt Gene Name: | FLRT2 |
