Anti-FKBP8 Antibody (CAB7085)
- SKU:
- CAB7085
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| 抗体名: | Anti-FKBP8 Antibody |
| 抗体コード: | CAB7085 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF IP |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-270 of human FKBP8 (NP_036313.3). |
| 申し込み: | WB IF IP |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 IP 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat, THP-1, BT-474, HeLa, HL-60, Mouse liver, Mouse brain, Mouse eye, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-270 of human FKBP8 (NP_036313.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QPPA EEAE QPGA LARE FLAA MEPE PAPA PAPE EWLD ILGN GLLR KKTL VPGP PGSS RPVK GQVV TVHL QTSL ENGT RVQE EPEL VFTL GDCD VIQA LDLS VPLM DVGE TAMV TADS KYCY GPQG SRSP YIPP HAAL CLEV TLKT AVDG PDLE MLTG QERV ALAN RKRE CGNA HYQR ADFV LAAN SYDL AIKA ITSS AKVD MTFE EEAQ LLQ |
| 遺伝子ID: | 23770 |
| Uniprot: | Q14318 |
| セルラーロケーション: | Cytoplasmic side, Mitochondrion membrane, Single-pass membrane protein |
| 計算された分子量: | 27kDa/44kDa |
| 観察された分子量: | 55kDa |
| 同義語: | FKBP8, FKBP38, FKBPr38 |
| バックグラウンド: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. |
| UniProt Protein Function: | FKBP8: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Chaperone; Isomerase; Mitochondrial; EC 5.2.1.8; Membrane protein, integral Chromosomal Location of Human Ortholog: 19p12 Cellular Component: endoplasmic reticulum membrane; membrane; mitochondrial membrane; integral to endoplasmic reticulum membrane Molecular Function:identical protein binding; protein binding; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; metal ion binding Biological Process: smoothened signaling pathway; camera-type eye development; protein peptidyl-prolyl isomerization; viral reproduction; apoptosis; regulation of gene expression; multicellular organism growth; cell fate specification; positive regulation of BMP signaling pathway; dorsoventral neural tube patterning; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14318 |
| NCBI GenInfo Identifier: | 193806337 |
| NCBI Gene ID: | 23770 |
| NCBI Accession: | Q14318.2 |
| UniProt Related Accession: | Q14318 |
| Molecular Weight: | 55kDa |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase FKBP8 |
| NCBI Synonym Full Names: | FKBP prolyl isomerase 8 |
| NCBI Official Symbol: | FKBP8 |
| NCBI Official Synonym Symbols: | FKBP38; FKBPr38 |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase FKBP8 |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase FKBP8 |
| UniProt Synonym Protein Names: | 38 kDa FK506-binding protein; 38 kDa FKBP; FKBP-38; hFKBP38; FK506-binding protein 8; FKBP-8; FKBPR38; Rotamase |
| Protein Family: | Peptidyl-prolyl cis-trans isomerase |
| UniProt Gene Name: | FKBP8 |
| UniProt Entry Name: | FKBP8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FKBP8 antibody (CAB7085) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunofluorescence analysis of A549 cells using FKBP8 antibody (CAB7085). Blue: DAPI for nuclear staining. |
 | Immunoprecipitation analysis of 200ug extracts of HeLa cells using 1ug FKBP8 antibody (CAB7085). Western blot was performed from the immunoprecipitate using FKBP8 antibody (CAB7085) at a dilition of 1:1000. |
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