Anti-FGFBP1 Antibody (CAB7458)
- SKU:
- CAB7458
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-FGFBP1 Antibody |
| 抗体コード: | CAB7458 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-234 of human FGFBP1 (NP_005121.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-549, HepG2, NIH/3T3, Mouse kidney, Mouse lung, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-234 of human FGFBP1 (NP_005121.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KKKV KNGL HSKV VSEQ KDTL GNTQ IKQK SRPG NKGK FVTK DQAN CRWA ATEQ EEGI SLKV ECTQ LDHE FSCV FAGN PTSC LKLK DERV YWKQ VARN LRSQ KDIC RYSK TAVK TRVC RKDF PESS LKLV SSTL FGNT KPRK EKTE MSPR EHIK GKET TPSS LAVT QTMA TKAP ECVE DPDM ANQR KTAL EFCG ETWS SLCT FFLS IVQD TSC |
| 遺伝子ID: | 9982 |
| Uniprot: | Q14512 |
| セルラーロケーション: | Cell membrane, Peripheral membrane protein, Secreted, extracellular space |
| 計算された分子量: | 26kDa |
| 観察された分子量: | 30kDa |
| 同義語: | FGFBP1, FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17 |
| バックグラウンド: | This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. |
| UniProt Protein Function: | FGFBP1: Acts as a carrier protein that release fibroblast- binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. Belongs to the fibroblast growth factor-binding protein family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4p15.32 Cellular Component: extracellular space; cell surface; plasma membrane Molecular Function:heparin binding; protein binding; fibroblast growth factor binding Biological Process: negative regulation of cell proliferation; cell-cell signaling; positive regulation of cell proliferation; positive regulation of fibroblast growth factor receptor signaling pathway; signal transduction |
| NCBI Summary: | This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q14512 |
| NCBI GenInfo Identifier: | 74739840 |
| NCBI Gene ID: | 9982 |
| NCBI Accession: | Q14512.1 |
| UniProt Secondary Accession: | Q14512,A8K5J2, |
| UniProt Related Accession: | Q14512 |
| Molecular Weight: | 234 |
| NCBI Full Name: | Fibroblast growth factor-binding protein 1 |
| NCBI Synonym Full Names: | fibroblast growth factor binding protein 1 |
| NCBI Official Symbol: | FGFBP1 |
| NCBI Official Synonym Symbols: | FGFBP; HBP17; FGF-BP; FGF-BP1; FGFBP-1 |
| NCBI Protein Information: | fibroblast growth factor-binding protein 1; FGF-binding protein 1; 17 kDa HBGF-binding protein; heparin-binding growth factor binding protein; 17 kDa heparin-binding growth factor-binding protein |
| UniProt Protein Name: | Fibroblast growth factor-binding protein 1 |
| UniProt Synonym Protein Names: | 17 kDa heparin-binding growth factor-binding protein; 17 kDa HBGF-binding protein; HBp17 |
| Protein Family: | Fibroblast growth factor-binding protein |
| UniProt Gene Name: | FGFBP1 |
| UniProt Entry Name: | FGFP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FGFBP1 antibody (CAB7458) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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