Anti-FFAR4 Antibody (CAB18689)
- SKU:
- CAB18689
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-FFAR4 Antibody |
| 抗体コード: | CAB18689 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human FFAR4. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HT-29, BxPC-3, RAW264.7, Mouse large intestine, Rat large intestine, Rat small intestine |
| 免疫原: | Recombinant protein of human FFAR4. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 338557 |
| Uniprot: | Q5NUL3 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 42KDa |
 | Western blot - FFAR4 Rabbit pAb (CAB18689) |
| 同義語: | |
| バックグラウンド: |
| UniProt Protein Function: | GPR120: Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid-binding; Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 10q23.33 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:fatty acid binding; peptide binding; taste receptor activity Biological Process: cellular response to hormone stimulus; hormone secretion; negative regulation of apoptosis; negative regulation of cytokine secretion; negative regulation of inflammatory response Disease: Body Mass Index Quantitative Trait Locus 10 |
| NCBI Summary: | This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q5NUL3 |
| NCBI GenInfo Identifier: | 82581671 |
| NCBI Gene ID: | 338557 |
| NCBI Accession: | Q5NUL3.2 |
| UniProt Secondary Accession: | Q5NUL3,Q495H1, Q5VY25, Q5VY26, Q7Z605, Q86SM7, |
| UniProt Related Accession: | Q5NUL3 |
| Molecular Weight: | 40,494 Da |
| NCBI Full Name: | Free fatty acid receptor 4 |
| NCBI Synonym Full Names: | free fatty acid receptor 4 |
| NCBI Official Symbol: | FFAR4 |
| NCBI Official Synonym Symbols: | GT01; PGR4; BMIQ10; GPR120; GPR129; O3FAR1 |
| NCBI Protein Information: | free fatty acid receptor 4 |
| UniProt Protein Name: | Free fatty acid receptor 4 |
| UniProt Synonym Protein Names: | G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; Omega-3 fatty acid receptor 1 |
| Protein Family: | Free fatty acid receptor |
| UniProt Gene Name: | FFAR4 |
| UniProt Entry Name: | FFAR4_HUMAN |