Anti-FCRL4 Antibody (CAB10329)
- SKU:
- CAB10329
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-FCRL4 Antibody |
| 抗体コード: | CAB10329 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-387 of human FCRL4 (NP_112572.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Raji, B cells, 293T, Mouse kidney, Mouse liver, Rat kidney, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-387 of human FCRL4 (NP_112572.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VLRC HRRR KEKL TAVK YTWN GNIL SISN KSWD LLIP QASS NNNG NYRC IGYG DEND VFRS NFKI IKIQ ELFP HPEL KATD SQPT EGNS VNLS CETQ LPPE RSDT PLHF NFFR DGEV ILSD WSTY PELQ LPTV WREN SGSY WCGA ETVR GNIH KHSP SLQI HVQR IPVS GVLL ETQP SGGQ AVEG EMLV LVCS VAEG TGDT TFSW HRED MQES LGRK TQRS LRAE LELP AIRQ SHAG GYYC TADN SYGP VQSM VLNV TVRE TPGN RDGL |
| 遺伝子ID: | 83417 |
| Uniprot: | Q96PJ5 |
| セルラーロケーション: | Cell membrane, Single-pass type I membrane protein |
| 計算された分子量: | 56kDa/57kDa |
| 観察された分子量: | 57kDa |
| 同義語: | FCRL4, CD307d, FCRH4, IGFP2, IRTA1 |
| バックグラウンド: | This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. |
| UniProt Protein Function: | FCRL4: May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response. A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2). A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1q23.1 Molecular Function:protein binding |
| NCBI Summary: | This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009] |
| UniProt Code: | Q96PJ5 |
| NCBI GenInfo Identifier: | 74761029 |
| NCBI Gene ID: | 83417 |
| NCBI Accession: | Q96PJ5.1 |
| UniProt Secondary Accession: | Q96PJ5,Q96PJ3, Q96RE0, |
| UniProt Related Accession: | Q96PJ5 |
| Molecular Weight: | 57kDa |
| NCBI Full Name: | Fc receptor-like protein 4 |
| NCBI Synonym Full Names: | Fc receptor like 4 |
| NCBI Official Symbol: | FCRL4 |
| NCBI Official Synonym Symbols: | FCRH4; IGFP2; IRTA1; CD307d |
| NCBI Protein Information: | Fc receptor-like protein 4 |
| UniProt Protein Name: | Fc receptor-like protein 4 |
| UniProt Synonym Protein Names: | Fc receptor homolog 4; FcRH4; IFGP family protein 2; hIFGP2; Immune receptor translocation-associated protein 1; CD_antigen: CD307d |
| Protein Family: | Fc receptor-like protein |
| UniProt Gene Name: | FCRL4 |
 | Western blot analysis of extracts of various cell lines, using FCRL4 antibody (CAB10329) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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