Anti-FAT1 Antibody (CAB14681)
- SKU:
- CAB14681
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-FAT1 Antibody |
| 抗体コード: | CAB14681 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 2700-2900 of human FAT1 (NP_005236.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 2700-2900 of human FAT1 (NP_005236.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LPKF SEPF YTFT VSED VPIG TEID LIRA EHSG TVLY SLVK GNTP ESNR DESF VIDR QSGR LKLE KSLD HETT KWYQ FSIL ARCT QDDH EMVA SVDV SIQV KDAN DNSP VFES SPYE AFIV ENLP GGSR VIQI RASD ADSG TNGQ VMYS LDQS QSVE VIES FAIN METG WITT LKEL DHEK RDNY QIKV VASD HGEK IQLS S |
| 遺伝子ID: | 2195 |
| Uniprot: | Q14517 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Nucleus, Single-pass type I membrane protein, perinuclear region |
| 計算された分子量: | 506kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | FAT1, CDHF7, CDHR8, FAT, ME5, hFat1 |
| バックグラウンド: | This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. |
| UniProt Protein Function: | FAT: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral Chromosomal Location of Human Ortholog: 4q35 Cellular Component: filopodium; focal adhesion; integral to plasma membrane; intercellular junction; lamellipodium; nucleus; perinuclear region of cytoplasm; plasma membrane Molecular Function:calcium ion binding; protein binding Biological Process: actin filament organization; anatomical structure morphogenesis; cell adhesion; cell migration; cell-cell adhesion; cell-cell signaling; establishment and/or maintenance of cell polarity; homophilic cell adhesion |
| NCBI Summary: | This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14517 |
| NCBI GenInfo Identifier: | 66346693 |
| NCBI Gene ID: | 2195 |
| NCBI Accession: | NP_005236.2 |
| UniProt Related Accession: | Q14517 |
| Molecular Weight: | 506,273 Da |
| NCBI Full Name: | protocadherin Fat 1 |
| NCBI Synonym Full Names: | FAT atypical cadherin 1 |
| NCBI Official Symbol: | FAT1 |
| NCBI Official Synonym Symbols: | FAT; ME5; CDHF7; CDHR8; hFat1 |
| NCBI Protein Information: | protocadherin Fat 1 |
| UniProt Protein Name: | Protocadherin Fat 1 |
| UniProt Synonym Protein Names: | Cadherin family member 7; Cadherin-related tumor suppressor homolog; Protein fat homolog |
| Protein Family: | Fatty acid transporter protein |
| UniProt Gene Name: | FAT1 |
| UniProt Entry Name: | FAT1_HUMAN |
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