Anti-EXOSC10 Antibody (CAB17519)
- SKU:
- CAB17519
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-EXOSC10 Antibody |
| 抗体コード: | CAB17519 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 586-885 of human EXOSC10 (NP_001001998.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-549, Raji, Mouse testis, Mouse spleen, Mouse lung, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 586-885 of human EXOSC10 (NP_001001998.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VAAG VKKS GPLP SAER LENV LFGP HDCS HAPP DGYP IIPT SGSV PVQK QASL FPDE KEDN LLGT TCLI ATAV ITLF NEPS AEDS KKGP LTVA QKKA QNIM ESFE NPFR MFLP SLGH RAPV SQAA KFDP STKI YEIS NRWK LAQV QVQK DSKE AVKK KAAE QTAA REQA KEAC KAAA EQAI SVRQ QVVL ENAA KKRE RATS DPRT TEQK QEKK RLKI SKKP KDPE PPEK EFTP YDYS QSDF KAFA GNSK SKVS SQFD PNKQ TPSG KKCI AAKK IKQS VGNK SMSF PTGK SDRG FRYN WPQR |
| 遺伝子ID: | 5394 |
| Uniprot: | Q01780 |
| セルラーロケーション: | |
| 計算された分子量: | 98kDa/100kDa |
| 観察された分子量: | 110kDa |
 | Western blot - EXOSC10 Polyclonal Antibody (CAB17519) |
| 同義語: | EXOSC10, PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4 |
| バックグラウンド: |
| UniProt Protein Function: | EXOSC10: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle; Nucleolus; EC 3.1.13.- Chromosomal Location of Human Ortholog: 1p36.22 Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; exosome (RNase complex); nucleus; nuclear exosome (RNase complex) Molecular Function:protein binding; exoribonuclease activity; nucleotide binding; 3'-5' exonuclease activity Biological Process: RNA processing; maturation of 5.8S rRNA; dosage compensation, by inactivation of X chromosome; mRNA catabolic process, nonsense-mediated decay |
| UniProt Code: | Q01780 |
| NCBI GenInfo Identifier: | 8928564 |
| NCBI Gene ID: | 5394 |
| NCBI Accession: | Q01780.2 |
| UniProt Secondary Accession: | Q01780,Q15158, B1AKQ0, B1AKQ1, |
| UniProt Related Accession: | Q01780 |
| Molecular Weight: | 885 |
| NCBI Full Name: | Exosome component 10 |
| NCBI Synonym Full Names: | exosome component 10 |
| NCBI Official Symbol: | EXOSC10 |
| NCBI Official Synonym Symbols: | p2; p3; p4; RRP6; PMSCL; Rrp6p; PM-Scl; PMSCL2; PM/Scl-100 |
| NCBI Protein Information: | exosome component 10; autoantigen PM-SCL; polymyositis/scleroderma autoantigen 2; polymyositis/scleroderma autoantigen 100 kDa; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen |
| UniProt Protein Name: | Exosome component 10 |
| UniProt Synonym Protein Names: | Autoantigen PM/Scl 2; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; Polymyositis/scleroderma autoantigen 100 kDa; PM/Scl-100; Polymyositis/scleroderma autoantigen 2 |
| Protein Family: | Exosome component |
| UniProt Gene Name: | EXOSC10 |
| UniProt Entry Name: | EXOSX_HUMAN |