Anti-ETFA Antibody (CAB19937)[KO Validated]
![Anti-ETFA Antibody (CAB19937)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/14420/14307/anti-etfa-antibody-cab19937ko-validated__72066__88541.1645802658.jpg?c=1 "Anti-ETFA Antibody (CAB19937)[KO Validated]")
- SKU:
- CAB19937
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
![Anti-ETFA Antibody (CAB19937)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/14420/14307/anti-etfa-antibody-cab19937ko-validated__72066__88541.1645802658.jpg?c=1&imbypass=on "Anti-ETFA Antibody (CAB19937)[KO Validated]")
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Description
| 抗体名: | Anti-ETFA Antibody [KO Validated] |
| 抗体コード: | CAB19937 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human ETFA. |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T |
| 免疫原: | Recombinant protein of human ETFA. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 2108 |
| Uniprot: | P13804 |
| セルラーロケーション: | Mitochondrion matrix |
| 計算された分子量: | 30kDa/35kDa |
| 観察された分子量: | 30KDa |
![Anti-ETFA Antibody [KO Validated] (CAB19937)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/q/774/A19937_1__27293.jpg) | Western blot analysis of extracts from normal (control) and ETFA knockout (KO) 293T cells, using ETFA antibody (CAB19937) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| 同義語: | ETFA, EMA, GA2, MADD |
| バックグラウンド: | ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ETFA: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Defects in ETFA are the cause of glutaric aciduria type 2A (GA2A); also known as glutaricaciduria IIA. GA2A is an autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Belongs to the ETF alpha-subunit/FixB family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Mitochondrial Chromosomal Location of Human Ortholog: 15q23-q25 Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:acyl-CoA binding; acyl-CoA dehydrogenase activity; electron carrier activity; FAD binding; oxidoreductase activity Biological Process: fatty acid beta-oxidation using acyl-CoA dehydrogenase; lipid homeostasis Disease: Multiple Acyl-coa Dehydrogenase Deficiency |
| NCBI Summary: | ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13804 |
| NCBI GenInfo Identifier: | 119636 |
| NCBI Gene ID: | 2108 |
| NCBI Accession: | P13804.1 |
| UniProt Secondary Accession: | P13804,Q53XN3, B4DT43, |
| UniProt Related Accession: | P13804 |
| Molecular Weight: | 30,026 Da |
| NCBI Full Name: | Electron transfer flavoprotein subunit alpha, mitochondrial |
| NCBI Synonym Full Names: | electron transfer flavoprotein alpha subunit |
| NCBI Official Symbol: | ETFA |
| NCBI Official Synonym Symbols: | EMA; GA2; MADD |
| NCBI Protein Information: | electron transfer flavoprotein subunit alpha, mitochondrial |
| UniProt Protein Name: | Electron transfer flavoprotein subunit alpha, mitochondrial |
| Protein Family: | Electron transfer flavoprotein |
| UniProt Gene Name: | ETFA |
| UniProt Entry Name: | ETFA_HUMAN |