Anti-ERRFI1 Antibody (CAB13099)
- SKU:
- CAB13099
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ERRFI1 Antibody |
| 抗体コード: | CAB13099 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 223-462 of human ERRFI1 (NP_061821.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Rat |
| ポジティブサンプル: | Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 223-462 of human ERRFI1 (NP_061821.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SYVS DQNG GVPD PNPP PPQT HRRL RRSH SGPA GSFN KPAI RISN CCIH RASP NSDE DKPE VPPR VPIP PRPV KPDY RRWS AEVT SSTY SDED RPPK VPPR EPLS PSNS RTPS PKSL PSYL NGVM PPTQ SFAP DPKY VSSK ALQR QNSE GSAS KVPC ILPI IENG KKVS STHY YLLP ERPP YLDK YEKF FREA EETN GGAQ IQPL PADC GISS ATEK PDSK TKMD LGGH VKRK HLSY VVSP |
| 遺伝子ID: | 54206 |
| Uniprot: | Q9UJM3 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Cytoplasmic side, Nucleus, Peripheral membrane protein |
| 計算された分子量: | 50kDa |
| 観察された分子量: | 50kDa |
| 同義語: | ERRFI1, GENE-33, MIG-6, MIG6, RALT |
| バックグラウンド: |
| UniProt Protein Function: | MIG-6: Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development. Interacts with ERBB2. Interacts with EGFR. Levels are very low in quiescent cells. Up-regulated by mitogens. Belongs to the MIG6 family. |
| UniProt Protein Details: | Protein type:Tumor suppressor; Inhibitor Chromosomal Location of Human Ortholog: 1p36 Cellular Component: extrinsic to internal side of plasma membrane; cytoplasm; nucleus Molecular Function:protein binding; protein kinase binding Biological Process: negative regulation of epidermal growth factor receptor activity; skin morphogenesis; response to stress; negative regulation of protein amino acid autophosphorylation; regulation of keratinocyte differentiation; alveolus development |
| NCBI Summary: | ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9UJM3 |
| NCBI GenInfo Identifier: | 27923810 |
| NCBI Gene ID: | 54206 |
| NCBI Accession: | Q9UJM3.1 |
| UniProt Related Accession: | Q9UJM3 |
| Molecular Weight: | 50kDa |
| NCBI Full Name: | ERBB receptor feedback inhibitor 1 |
| NCBI Synonym Full Names: | ERBB receptor feedback inhibitor 1 |
| NCBI Official Symbol: | ERRFI1 |
| NCBI Official Synonym Symbols: | MIG6; RALT; MIG-6; GENE-33 |
| NCBI Protein Information: | ERBB receptor feedback inhibitor 1 |
| UniProt Protein Name: | ERBB receptor feedback inhibitor 1 |
| UniProt Synonym Protein Names: | Mitogen-inducible gene 6 protein; MIG-6 |
| Protein Family: | ERBB receptor feedback inhibitor |
| UniProt Gene Name: | ERRFI1 |
| UniProt Entry Name: | ERRFI_HUMAN |
 | Western blot analysis of extracts of rat lung, using ERRFI1 antibody (CAB13099) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min. |
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