Anti-EPB42 Antibody (CAB17481)
- SKU:
- CAB17481
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-EPB42 Antibody |
| 抗体コード: | CAB17481 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 10-240 of human EPB42 (NP_001107606). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | A-549, 293T, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 10-240 of human EPB42 (NP_001107606). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | CDFQ AARN NEEH HTKA LSSR RLFV RRGQ PFTI ILYF RAPV RAFL PALK KVAL TAQT GEQP SKIN RTQA TFPI SSLG DRKW WSAV VEER DAQS WTIS VTTP ADAV IGHY SLLL QVSG RKQL LLGQ FTLL FNPW NRED AVFL KNEA QRME YLLN QNGL IYLG TADC IQAE SWDF GQFE GDVI DLSL RLLS KDKQ VEKW SQPV HVAR VLGA LLHF LKEQ RVLP TPQT QATQ EGA |
| 遺伝子ID: | 2038 |
| Uniprot: | P16452 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 77kDa |
 | Western blot - EPB42 Polyclonal Antibody (CAB17481) |
| 同義語: | PA, SPH5, EPB42 |
| バックグラウンド: | Erythrocyte membrane protein band 4.2 is an ATP-binding protein which may regulate the association of protein 3 with ankyrin. It probably has a role in erythrocyte shape and mechanical property regulation. Mutations in the EPB42 gene are associated with recessive spherocytic elliptocytosis and recessively transmitted hereditary hemolytic anemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | Epb4.2: Probably plays an important role in the regulation of erythrocyte shape and mechanical properties. Defects in EPB42 are the cause of spherocytosis type 5 (SPH5); also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported. Belongs to the transglutaminase superfamily. Transglutaminase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 15q15-q21 Cellular Component: cortical cytoskeleton; cytoskeleton; plasma membrane Molecular Function:protein binding; structural constituent of cytoskeleton; protein-glutamine gamma-glutamyltransferase activity; ATP binding Biological Process: spleen development; regulation of cell shape; iron ion homeostasis; erythrocyte maturation; hemoglobin metabolic process; cell morphogenesis; peptide cross-linking Disease: Spherocytosis, Type 5 |
| NCBI Summary: | Erythrocyte membrane protein band 4.2 is an ATP-binding protein which may regulate the association of protein 3 with ankyrin. It probably has a role in erythrocyte shape and mechanical property regulation. Mutations in the EPB42 gene are associated with recessive spherocytic elliptocytosis and recessively transmitted hereditary hemolytic anemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P16452 |
| NCBI GenInfo Identifier: | 215274164 |
| NCBI Gene ID: | 2038 |
| NCBI Accession: | P16452.3 |
| UniProt Secondary Accession: | P16452,Q4KKX0, Q4VB97, |
| UniProt Related Accession: | P16452 |
| Molecular Weight: | 69,455 Da |
| NCBI Full Name: | Erythrocyte membrane protein band 4.2 |
| NCBI Synonym Full Names: | erythrocyte membrane protein band 4.2 |
| NCBI Official Symbol: | EPB42 |
| NCBI Official Synonym Symbols: | PA; SPH5 |
| NCBI Protein Information: | erythrocyte membrane protein band 4.2 |
| UniProt Protein Name: | Erythrocyte membrane protein band 4.2 |
| Protein Family: | Erythrocyte membrane protein |
| UniProt Gene Name: | EPB42 |
| UniProt Entry Name: | EPB42_HUMAN |