Anti-ENAH Antibody (CAB17932)
- SKU:
- CAB17932
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-ENAH Antibody |
| 抗体コード: | CAB17932 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 412-591 of human ENAH (NP_001008493.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-251MG, C6, rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 412-591 of human ENAH (NP_001008493.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | FPSG GNAI GVNS ASSK TDTG RGNG PLPL GGSG LMEE MSAL LARR RRIA EKGS TIET EQKE DKGE DSEP VTSK ASST STPE PTRK PWER TNTM NGSK SPVI SRRD SPRK NQIV FDNR SYDS LHRP KSTP LSQP SANG VQTE GLDY DRLK QDIL DEMR KELT KLKE ELID AIRQ ELSK SNTA |
| 遺伝子ID: | 55740 |
| Uniprot: | Q8N8S7 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 110kDa |
 | Western blot - ENAH Polyclonal Antibody (CAB17932) |
| 同義語: | ENA, MENA, NDPP1, ENAH |
| バックグラウンド: |
| UniProt Protein Function: | Mena: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation. Required for the actin-based mobility of Listeria monocytogenes. Homotetramer. Interacts with APBB1IP, APBB1, PFN1 and ROBO4. Isoforms, containing the polyproline-rich regions with PPLP motifs, bind the WW domain of APBB1IP. Isoforms, containing the PPSY motif, bind, in vitro, to the WW2 and WW3 domains of NEDD4 and to the WW1 domain of YAP1. Binds the SH3 domain of BAIAP2-alpha but only after the autoinhibitory region of BAIAP2-alpha has been blocked by interaction with CDC42. Interacts, via the EVH1/WH1 domain, with the Pro-rich domains from VCL, ZYX and Listeria monocytogenes actA and with TES (via LIM domains). The TES LIM domain and the Pro-rich domains from VCL or ZYX compete for the same binding site. Interaction with ZYX is important for targeting ENAH to focal adhesions and enhances production of actin-rich structures at the apical surface of cells. Interacts, through the Pro-rich region, with the C-terminal SH3 domain of DNMPB. Binds GPHN. Interacts with FAT1 (via EVH1 domains). Heterotrimer with TES and ACTL7A. Expressed in myoepithelia of parotid, breast, bronchial glands and sweat glands. Expressed in colon-rectum muscolaris mucosae epithelium, pancreas acinar ductal epithelium, endometrium epithelium, prostate fibromuscolar stroma and placenta vascular media. Overexpressed in a majority of breast cancer cell lines and primary breast tumor lesions. Belongs to the Ena/VASP family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 1q42.12 Cellular Component: cell junction; cytoplasm; cytosol; filopodium; focal adhesion; lamellipodium; plasma membrane; stress fiber; synapse Molecular Function:actin binding; protein binding; SH3 domain binding; WW domain binding Biological Process: actin polymerization and/or depolymerization; axon guidance; intracellular transport; neural tube closure; T cell receptor signaling pathway |
| UniProt Code: | Q8N8S7 |
| NCBI GenInfo Identifier: | 48428086 |
| NCBI Gene ID: | 55740 |
| NCBI Accession: | Q8N8S7.2 |
| UniProt Secondary Accession: | Q8N8S7,Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8 D0PQI2, |
| UniProt Related Accession: | Q8N8S7 |
| Molecular Weight: | 60,349 Da |
| NCBI Full Name: | Protein enabled homolog |
| NCBI Synonym Full Names: | enabled homolog (Drosophila) |
| NCBI Official Symbol: | ENAH |
| NCBI Official Synonym Symbols: | ENA; MENA; NDPP1 |
| NCBI Protein Information: | protein enabled homolog |
| UniProt Protein Name: | Protein enabled homolog |
| Protein Family: | Menaquinone reductase |
| UniProt Gene Name: | ENAH |
| UniProt Entry Name: | ENAH_HUMAN |