Anti-EMG1 Antibody (CAB4421)

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SKU:
CAB4421
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
EMG1
Synonyms:
C2F
Synonyms:
Grcc2f
Synonyms:
NEP1
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Description

I抗体名:EMG1 Rabbit pAb
抗体コード:CAB4421
サイズ:20uL, 50uL, 100uL
同義語:EMG1, C2F, Grcc2f, NEP1
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-244 of human EMG1 (NP_006322.4).
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
ポジティブサンプル:HeLa, HepG2, Mouse heart, Rat liver
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-244 of human EMG1 (NP_006322.4).
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MAAP SDGF KPRE RSGG EQAQ DWDA LPPK RPRL GAGN KIGG RRLI VVLE GASL ETVK VGKT YELL NCDK HKSI LLKN GRDP GEAR PDIT HQSL LMLM DSPL NRAG LLQV YIHT QKNV LIEV NPQT RIPR TFDR FCGL MVQL LHKL SVRA ADGP QKLL KVIK NPVS DHFP VGCM KVGT SFSI PVVS DVRE LVPS SDPI VFVV GAFA HGKV SVEY TEKM VSIS NYPL SAAL TCAK LTTA FEEV WGVI
遺伝子ID:10436
Uniprot:Q92979
セルラーロケーション:Nucleus, nucleolus
計算された分子量:26kDa
観察された分子量:27kDa
UniProt Protein Function:C2F: Involved in 40S ribosomal subunit biogenesis and 18S rRNA processing. Specifically catalyzes the N1-methylation of pseudouridine at position 1248 (Psi1248) in 18S rRNA. Thus, appears to be the methyltransferase involved in the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) in position 1248 in 18S rRNA. Is not able to methylate uridine at this position. Defects in EMG1 are the cause of Bowen-Conradi syndrome (BWCNS). BWCNS is a combination of malformations characterized in newborns by low birth weight, microcephaly, mild joint restriction, a prominent nose, micrognathia, fifth finger clinodactyly, and 'rocker-bottom' feet. The syndrome is transmitted as an autosomal recessive trait. The prognosis is poor, with all infants dying within the first few months of life. Belongs to the NEP1 family.
UniProt Protein Details:

Protein type:EC 2.1.1.-; RNA-binding; Nucleolus

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: cytoplasm; nucleolus; nucleus

Molecular Function:rRNA binding; RNA binding

Biological Process: ribosomal small subunit biogenesis and assembly; rRNA methylation; rRNA processing

Disease: Bowen-conradi Syndrome

NCBI Summary:This gene encodes an essential, conserved eukaryotic protein involved in ribosome biogenesis. In yeast, the related protein is a component of the small subunit processome and is essential for biogenesis of the ribosomal 40S subunit. A mutation in this gene has been associated with Bowen-Conradi syndrome.[provided by RefSeq, May 2010]
UniProt Code:Q92979
NCBI GenInfo Identifier:20532172
NCBI Gene ID:10436
NCBI Accession:Q92979.4
UniProt Secondary Accession:Q92979,O00675, O00726,
UniProt Related Accession:Q92979
Molecular Weight:244
NCBI Full Name:Ribosomal RNA small subunit methyltransferase NEP1
NCBI Synonym Full Names:EMG1 N1-specific pseudouridine methyltransferase
NCBI Official Symbol:EMG1  
NCBI Official Synonym Symbols:C2F; NEP1; Grcc2f  
NCBI Protein Information:ribosomal RNA small subunit methyltransferase NEP1; EMG1 nucleolar protein homolog; essential for mitotic growth 1; ribosome biogenesis protein NEP1; 18S rRNA Psi1248 methyltransferase; 18S rRNA (pseudouridine(1248)-N1)-methyltransferase; 18S rRNA (pseudouridine-N1-)-methyltransferase NEP1
UniProt Protein Name:Ribosomal RNA small subunit methyltransferase NEP1
UniProt Synonym Protein Names:18S rRNA (pseudouridine(1248)-N1)-methyltransferase; 18S rRNA Psi1248 methyltransferase; Nucleolar protein EMG1 homolog; Protein C2f; Ribosome biogenesis protein NEP1
UniProt Gene Name:EMG1  
UniProt Entry Name:NEP1_HUMAN
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