Anti-ECSIT Antibody (CAB7804)
- SKU:
- CAB7804
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-ECSIT Antibody |
| 抗体コード: | CAB7804 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-296 of human ECSIT (NP_001135936.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HepG2, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-296 of human ECSIT (NP_001135936.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SEQS LVPS PPEP RQRP TKAL VPFE DLFG QAPG GERD KASF LQTV QKFA EHSV RKRG HIDF IYLA LRKM REYG VERD LAVY NQLL NIFP KEVF RPRN IIQR IFVH YPRQ QECG IAVL EQME NHGV MPNK ETEF LLIQ IFGR KSYP MLKL VRLK LWFP RFMN VNPF PVPR DLPQ DPVE LAMF GLRH MEPD LSAR VTIY QVPL PKDS TGAA DPPQ PHIV GSGR DAGG VEPL LPDA AGPG VCEE WLGQ LRV |
| 遺伝子ID: | 51295 |
| Uniprot: | Q9BQ95 |
| セルラーロケーション: | Cytoplasm, Mitochondrion, Nucleus |
| 計算された分子量: | 24kDa/33kDa/49kDa |
| 観察された分子量: | 49kDa |
| 同義語: | ECSIT, SITPEC |
| バックグラウンド: |
| UniProt Protein Function: | ECSIT: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development. Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase. Belongs to the ECSIT family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; Adaptor/scaffold Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrion; nucleoplasm; nucleus Molecular Function:oxidoreductase activity, acting on NADH or NADPH; protein binding Biological Process: mitochondrial respiratory chain complex I assembly; regulation of oxidoreductase activity |
| UniProt Code: | Q9BQ95 |
| NCBI GenInfo Identifier: | 74752234 |
| NCBI Gene ID: | 51295 |
| NCBI Accession: | Q9BQ95.1 |
| UniProt Secondary Accession: | Q9BQ95,Q96HQ7, Q9NYI1, E9PAN9, K7EMM0, |
| UniProt Related Accession: | Q9BQ95 |
| Molecular Weight: | 33,938 Da |
| NCBI Full Name: | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial |
| NCBI Synonym Full Names: | ECSIT signalling integrator |
| NCBI Official Symbol: | ECSIT |
| NCBI Official Synonym Symbols: | SITPEC |
| NCBI Protein Information: | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial |
| UniProt Protein Name: | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial |
| UniProt Synonym Protein Names: | Protein SITPEC |
| Protein Family: | Evolutionarily conserved signaling intermediate |
| UniProt Gene Name: | ECSIT |
| UniProt Entry Name: | ECSIT_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ECSIT antibody (CAB7804) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using ECSIT antibody (CAB7804) at dilution of 1:100 (40x lens). |
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