Anti-DPPA4 Antibody (CAB13725)
- SKU:
- CAB13725
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-DPPA4 Antibody |
| 抗体コード: | CAB13725 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 15-304 of human DPPA4 (NP_060659.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | LO2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 15-304 of human DPPA4 (NP_060659.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KGKE WTST EKSR EEDQ QASN QPNS IALP GTSA KRTK EKMS IKGS KVLC PKKK AEHT DNPR PQKK IPIP PLPS KLPP VNLI HRDI LRAW CQQL KLSS KGQK LDAY KRLC AFAY PNQK DFPS TAKE AKIR KSLQ KKLK VEKG ETSL QSSE THPP EVAL PPVG EPPA LENS TALL EGVN TVVV TTSA PEAL LASW ARIS ARAR TPEA VESP QEAS GVRW CVVH GKSL PADT DGWV HLQF HAGQ AWVP EKQE GRVS ALFL LPAS NFPP PHLE DNML CPKC VHRN KVLI KSLQ WE |
| 遺伝子ID: | 55211 |
| Uniprot: | Q7L190 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 33kDa |
| 観察された分子量: | 38kDa |
| 同義語: | DPPA4, 2410091M23Rik |
| バックグラウンド: | This gene encodes a nuclear factor that is involved in the maintenance of pluripotency in stem cells and essential for embryogenesis. The encoded protein has a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. Mice with a homozygous knockout of the orthologous gene die during late embryonic development or within hours after birth. Knockout embryos are normal in size at embryonic day 18.5 but exhibit skeletal and lung tissue abnormalities. This gene, when mutated, is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers and is thought to play an important role in tumor progression. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | DPPA4: May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage. |
| UniProt Protein Details: | Protein type:Cell development/differentiation Chromosomal Location of Human Ortholog: 3q13.13 Cellular Component: nucleoplasm Molecular Function:protein binding Biological Process: somatic stem cell maintenance |
| UniProt Code: | Q7L190 |
| NCBI GenInfo Identifier: | 296434484 |
| NCBI Gene ID: | 55211 |
| NCBI Accession: | Q7L190.2 |
| UniProt Secondary Accession: | Q7L190,Q9H9N5, Q9NVI6, A8K4M7, |
| UniProt Related Accession: | Q7L190 |
| Molecular Weight: | 33,541 Da |
| NCBI Full Name: | Developmental pluripotency-associated protein 4 |
| NCBI Synonym Full Names: | developmental pluripotency associated 4 |
| NCBI Official Symbol: | DPPA4 |
| NCBI Official Synonym Symbols: | 2410091M23Rik |
| NCBI Protein Information: | developmental pluripotency-associated protein 4 |
| UniProt Protein Name: | Developmental pluripotency-associated protein 4 |
| Protein Family: | Developmental pluripotency-associated protein |
| UniProt Gene Name: | DPPA4 |
| UniProt Entry Name: | DPPA4_HUMAN |
 | Western blot analysis of extracts of LO2 cells, using DPPA4 antibody (CAB13725) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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