Anti-DNAJC19 Antibody (CAB14961)
- SKU:
- CAB14961
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-DNAJC19 Antibody |
| 抗体コード: | CAB14961 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-116 of human DNAJC19 (NP_660304.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HT-1080, Mouse pancreas, Mouse small intestine, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-116 of human DNAJC19 (NP_660304.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAST VVAV GLTI AAAG FAGR YVLQ AMKH MEPQ VKQV FQSL PKSA FSGG YYRG GFEP KMTK REAA LILG VSPT ANKG KIRD AHRR IMLL NHPD KGGS PYIA AKIN EAKD LLEG QAKK |
| 遺伝子ID: | 131118 |
| Uniprot: | Q96DA6 |
| セルラーロケーション: | Mitochondrion inner membrane, Single-pass membrane protein |
| 計算された分子量: | 10kDa/12kDa |
| 観察された分子量: | 12kDa |
| 同義語: | DNAJC19, PAM18, TIM14, TIMM14 |
| バックグラウンド: | The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 2, 6, 10, 14 and 19. |
| UniProt Protein Function: | DNAJC19: Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity. Defects in DNAJC19 are the cause of 3-methylglutaconic aciduria type 5 (MGA5); also known as dilated cardiomyopathy with ataxia (DCMA). MGA5 is an autosomal recessive disorder characterized by early-onset dilated cardiomyopathy, growth failure, cerebellar ataxia causing significant motor delays, testicular dysgenesis, growth failure, and significant increases in urine organic acids, particularly 3-methylglutaconic acid and 3-methylglutaric acid. Belongs to the TIM14 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Chaperone; Mitochondrial Chromosomal Location of Human Ortholog: 3q26.33 Cellular Component: protein complex; mitochondrion; mitochondrial inner membrane; integral to membrane Molecular Function:protein binding Biological Process: genitalia development; cellular protein metabolic process; protein folding; visual perception; protein targeting to mitochondrion Disease: 3-methylglutaconic Aciduria, Type V |
| NCBI Summary: | The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 2, 6, 10, 14 and 19. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q96DA6 |
| NCBI GenInfo Identifier: | 74760780 |
| NCBI Gene ID: | 131118 |
| NCBI Accession: | Q96DA6.3 |
| UniProt Secondary Accession: | Q96DA6,B2R4B1, C9JBV1, |
| UniProt Related Accession: | Q96DA6 |
| Molecular Weight: | 116 |
| NCBI Full Name: | Mitochondrial import inner membrane translocase subunit TIM14 |
| NCBI Synonym Full Names: | DnaJ (Hsp40) homolog, subfamily C, member 19 |
| NCBI Official Symbol: | DNAJC19 |
| NCBI Official Synonym Symbols: | PAM18; TIM14; TIMM14 |
| NCBI Protein Information: | mitochondrial import inner membrane translocase subunit TIM14; homolog of yeast TIM14 |
| UniProt Protein Name: | Mitochondrial import inner membrane translocase subunit TIM14 |
| UniProt Synonym Protein Names: | DnaJ homolog subfamily C member 19 |
| UniProt Gene Name: | DNAJC19 |
| UniProt Entry Name: | TIM14_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DNAJC19 Rabbit pAb (CAB14961) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Immunofluorescence analysis of Hela cells using DNAJC19 antibody (CAB14961) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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