Anti-DNAH5 Antibody (CAB17472)
- SKU:
- CAB17472
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-DNAH5 Antibody |
| 抗体コード: | CAB17472 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | IF |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-650 of human DNAH5 (NP_001360.1). |
| 申し込み: | IF |
| 推奨希釈: | IF 1:50 - 1:200 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-650 of human DNAH5 (NP_001360.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VTNQ IISA CKAY ITNN GTAS IWNQ PQDV VEEK ILSA IKLK QEYQ LCFH KTKQ KLKQ NPNA KQFD FSEM YIFG KFET FHRR LAKI IDIF TTLK TYSV LQDS TIEG LEDM ATKY QGIV ATIK KKEY NFLD QRKM DFDQ DYEE FCKQ TNDL HNEL RKFM DVTF AKIQ NTNQ ALRM LKKF ERLN IPNL GIDD KYQL ILEN YGAD IDMI SKLY TKQK YDPP LARN QPPI AGKI LWAR QLFH RIQQ PMQL FQQH PAV |
| 遺伝子ID: | 1767 |
| Uniprot: | Q8TE73 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | CILD3, DNAHC5, HL1, KTGNR, PCD, DNAH5 |
| バックグラウンド: | This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009] |
| UniProt Protein Function: | DNAH5: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles. Defects in DNAH5 are the cause of primary ciliary dyskinesia type 3 (CILD3). CILD3 is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Defects in DNAH5 are a cause of Kartagener syndrome (KTGS). KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera). Belongs to the dynein heavy chain family. |
| UniProt Protein Details: | Protein type:Motor; Microtubule-binding; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 5p15.2 Cellular Component: microtubule; axonemal dynein complex; axoneme Molecular Function:ATPase activity; microtubule motor activity; ATP binding Biological Process: metabolic process; lateral ventricle development Disease: Ciliary Dyskinesia, Primary, 3 |
| NCBI Summary: | This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q8TE73 |
| NCBI GenInfo Identifier: | 19115954 |
| NCBI Gene ID: | 1767 |
| NCBI Accession: | NP_001360.1 |
| UniProt Secondary Accession: | Q8TE73,Q92860, Q96L74, Q9H5S7, Q9HCG9, |
| UniProt Related Accession: | Q8TE73 |
| Molecular Weight: | 529,021 Da |
| NCBI Full Name: | dynein heavy chain 5, axonemal |
| NCBI Synonym Full Names: | dynein, axonemal, heavy chain 5 |
| NCBI Official Symbol: | DNAH5 |
| NCBI Official Synonym Symbols: | HL1; PCD; CILD3; KTGNR; DNAHC5 |
| NCBI Protein Information: | dynein heavy chain 5, axonemal; ciliary dynein heavy chain 5; axonemal beta dynein heavy chain 5; dynein, axonemal, heavy polypeptide 5 |
| UniProt Protein Name: | Dynein heavy chain 5, axonemal |
| UniProt Synonym Protein Names: | Axonemal beta dynein heavy chain 5; Ciliary dynein heavy chain 5 |
| Protein Family: | Dynein |
| UniProt Gene Name: | DNAH5 |
| UniProt Entry Name: | DYH5_HUMAN |