Anti-DHX38 Antibody (CAB4341)
- SKU:
- CAB4341
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-DHX38 Antibody |
| 抗体コード: | CAB4341 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1133-1227 of human DHX38 (NP_054722.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, SKOV3, U-87MG, MCF7, DU145, Mouse testis, Mouse thymus |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1133-1227 of human DHX38 (NP_054722.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VTAV DGEW LAEL GPMF YSVK QAGK SRQE NRRR AKEE ASAM EEEM ALAE EQLR ARRQ EQEK RSPL GSVR STKI YTPG RKEQ GEPM TPRR TPAR FGL |
| 遺伝子ID: | 9785 |
| Uniprot: | Q92620 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 60kDa/140kDa |
| 観察された分子量: | 140kDa |
| 同義語: | DHX38, DDX38, PRP16, PRPF16 |
| バックグラウンド: | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process. |
| UniProt Protein Function: | DHX38: Probable ATP-binding RNA helicase involved in pre-mRNA splicing. Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily. |
| UniProt Protein Details: | Protein type:Spliceosome; EC 3.6.4.13; RNA-binding; RNA processing; Helicase; RNA splicing Chromosomal Location of Human Ortholog: 16q22 Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus Molecular Function:protein binding; ATP-dependent RNA helicase activity; ATP binding Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; RNA splicing; gene expression; mRNA 3'-end processing; termination of RNA polymerase II transcription |
| NCBI Summary: | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92620 |
| NCBI GenInfo Identifier: | 85700389 |
| NCBI Gene ID: | 9785 |
| NCBI Accession: | Q92620.2 |
| UniProt Related Accession: | Q92620 |
| Molecular Weight: | 140kDa |
| NCBI Full Name: | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 |
| NCBI Synonym Full Names: | DEAH-box helicase 38 |
| NCBI Official Symbol: | DHX38 |
| NCBI Official Synonym Symbols: | RP84; DDX38; PRP16; PRPF16 |
| NCBI Protein Information: | pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 |
| UniProt Protein Name: | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 |
| UniProt Synonym Protein Names: | ATP-dependent RNA helicase DHX38; DEAH box protein 38 |
| UniProt Gene Name: | DHX38 |
| UniProt Entry Name: | PRP16_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DHX38 antibody (CAB4341) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using DHX38 antibody (CAB4341) at dilution of 1:150 (40x lens). |
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