Anti-DGCR14 Antibody (CAB13174)
- SKU:
- CAB13174
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-DGCR14 Antibody |
| 抗体コード: | CAB13174 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DGCR14 (NP_073210.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | A-549, NIH/3T3, Mouse testis, Mouse thymus |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DGCR14 (NP_073210.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | METP GASA SSLL LPAA SRPP RKRE AGEA GAAT SKQR VLDE EEYI EGLQ TVIQ RDFF PDVE KLQA QKEY LEAE ENGD LERM RQIA IKFG SALG KMSR EPPP PYVT PATF ETPE VHAG TGVV GNKP RPRG RGLE DGEA GEEE EKEP LPSL DVFL SRYT SEDN ASFQ EIME VAKE RSRA RHAW LYQA EEEF EKRQ KDNL ELPS AEHQ AIES SQAS VETW KYKA KNSL MYYP EGVP DEEQ LFKK PRQV VHKN TRFL RDPF SQAL SRCQ LQQA AALN AQHK QGKV GPDG KELI PQES PRVG GFGF |
| 遺伝子ID: | 8220 |
| Uniprot: | Q96DF8 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 52kDa |
| 観察された分子量: | 53kDa |
| 同義語: | DGCR14, DGCR13, DGS-H, DGS-I, DGSH, DGSI, ES2, ESS-2, Es2el, bis1 |
| バックグラウンド: | This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | DGCR14: involved in pre-mRNA splicing. One of the many proteins in the spliceosome C complex. Defects in this gene play a part in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS). |
| UniProt Protein Details: | Protein type:Spliceosome; RNA splicing; RNA processing; RNA-binding Chromosomal Location of Human Ortholog: 22q11.21|22q11.2 Cellular Component: nucleus Molecular Function:protein binding Biological Process: nervous system development; nuclear mRNA splicing, via spliceosome Disease: Velocardiofacial Syndrome |
| NCBI Summary: | This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q96DF8 |
| NCBI GenInfo Identifier: | 27805463 |
| NCBI Gene ID: | 8220 |
| NCBI Accession: | Q96DF8.1 |
| UniProt Secondary Accession: | Q96DF8,Q49AH7, Q9BTZ4, |
| UniProt Related Accession: | Q96DF8 |
| Molecular Weight: | 52,568 Da |
| NCBI Full Name: | Protein DGCR14 |
| NCBI Synonym Full Names: | DiGeorge syndrome critical region gene 14 |
| NCBI Official Symbol: | DGCR14 |
| NCBI Official Synonym Symbols: | ES2; DGSH; DGSI; DGS-H; DGS-I; Es2el; DGCR13 |
| NCBI Protein Information: | protein DGCR14 |
| UniProt Protein Name: | Protein DGCR14 |
| UniProt Synonym Protein Names: | DiGeorge syndrome critical region 13; DiGeorge syndrome critical region 14; DiGeorge syndrome protein H; DGS-H; Protein ES2 |
| Protein Family: | Protein |
| UniProt Gene Name: | DGCR14 |
| UniProt Entry Name: | DGC14_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DGCR14 antibody (CAB13174) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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