Anti-DDX6 Antibody (RACO0494)
- SKU:
- RACO0494
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 商品名: | DDX6 Antibody |
| Product SKU: | RACO0494 |
| サイズ: | 50ul |
| 宿主種: | Homo sapiens (Human) |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | IHC:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | A synthesized peptide derived from human DDX6 |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573). |
| シノニム: | Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK), DDX6, HLR2 RCK |
 | IHC image of RACO0494 diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| UniProt Protein Function: | DDX6: an oncogenic ATP-dependent helicase of the DEAD box family. Interacts with argonaute proteins, Ago1 and Ago2, and is a general repressor of translation in human cells by miRNA-induced gene silencing. In the process of mRNA degradation, may play a role in mRNA decapping. |
| UniProt Protein Details: | Protein type:RNA processing; Oncoprotein; EC 3.6.4.13; Helicase; RNA-binding Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: intracellular membrane-bound organelle; membrane; stress granule; cytoplasm; cytosol Molecular Function:protein domain specific binding; protein binding; helicase activity; ATP binding; RNA helicase activity Biological Process: gene expression; cytoplasmic mRNA processing body assembly; mRNA catabolic process, deadenylation-dependent decay |
| NCBI Summary: | This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P26196 |
| NCBI GenInfo Identifier: | 116241327 |
| NCBI Gene ID: | 1656 |
| NCBI Accession: | P26196.2 |
| UniProt Secondary Accession: | P26196,P54823, |
| UniProt Related Accession: | P26196 |
| Molecular Weight: | 483 |
| NCBI Full Name: | Probable ATP-dependent RNA helicase DDX6 |
| NCBI Synonym Full Names: | DEAD (Asp-Glu-Ala-Asp) box helicase 6 |
| NCBI Official Symbol: | DDX6 |
| NCBI Official Synonym Symbols: | P54; RCK; HLR2 |
| NCBI Protein Information: | probable ATP-dependent RNA helicase DDX6; DEAD box-6; oncogene RCK; DEAD box protein 6; ATP-dependent RNA helicase p54; DEAD (Asp-Glu-Ala-Asp) box polypeptide 6; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD) |
| UniProt Protein Name: | Probable ATP-dependent RNA helicase DDX6 |
| UniProt Synonym Protein Names: | ATP-dependent RNA helicase p54; DEAD box protein 6; Oncogene RCK |
| UniProt Gene Name: | DDX6 |
| UniProt Entry Name: | DDX6_HUMAN |