Anti-CRTC2 Antibody (CAB10682)
- SKU:
- CAB10682
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-CRTC2 Antibody |
| 抗体コード: | CAB10682 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 434-693 of human CRTC2 (NP_859066.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 434-693 of human CRTC2 (NP_859066.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | PLSL LAGP ADAR RSQQ QLPK QFSP TMSP TLSS ITQG VPLD TSKL STDQ RLPP YPYS SPSL VLPT QPHT PKSL QQPG LPSQ SCSV QSSG GQPP GRQS HYGT PYPP GPSG HGQQ SYHR PMSD FNLG NLEQ FSME SPSA SLVL DPPG FSEG PGFL GGEG PMGG PQDP HTFN HQNL THCS RHGS GPNI ILTG DSSP GFSK EIAA ALAG VPGF EVSA AGLE LGLG LEDE LRME PLGL EGLN MLSD PCAL LPDP AVEE SFRS DRLQ |
| 遺伝子ID: | 200186 |
| Uniprot: | Q53ET0 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 73kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | CRTC2, TORC-2, TORC2 |
| バックグラウンド: | This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. |
| UniProt Protein Function: | TORC2: the transducer of regulated CREB protein 2 (TORC2) is a cAMP responsive coactivator that, in concert with LKB1 and AMPK, controls glucose homeostasis in the liver. Under fasting conditions, cytoplasmic TORC2 is transported to the nucleus where it binds to CREB and stimulates gluconeogenisis. Re-feeding and the ensuing insulin response inhibits gluconeogenic gene expression by promoting the phosphorylation, cytoplasmic export and degradation of TORC2. TORC2 is phosphorylated by the kinase QIK which in turn is activated by phosphorylation at Ser358 by insulin-activated Akt2. Phosphorylated TORC2 is subsequently ubiquitinylated at Lys 628 and degraded by the 26S proteasome. TORC2 protein levels and activity are increased in diabetes owing to a block in TORC2 phosphorylation, implicating this pathway in the pathogenesis of diabetes. The CREB/TORC2 regulatory axis controls the normal pattern of germinal center (GC) B cell gene activation/repression that promotes B cell development and circumvents GC lymphomagenesis. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:cAMP response element binding protein binding; protein binding Biological Process: activation of CREB transcription factor; gluconeogenesis; glucose homeostasis; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q53ET0 |
| NCBI GenInfo Identifier: | 167009135 |
| NCBI Gene ID: | 200186 |
| NCBI Accession: | Q53ET0.2 |
| UniProt Secondary Accession: | Q53ET0,Q6UUV8, Q7Z3X7, Q8N332, |
| UniProt Related Accession: | Q53ET0 |
| Molecular Weight: | 73,302 Da |
| NCBI Full Name: | CREB-regulated transcription coactivator 2 |
| NCBI Synonym Full Names: | CREB regulated transcription coactivator 2 |
| NCBI Official Symbol: | CRTC2 |
| NCBI Official Synonym Symbols: | TORC2; TORC-2 |
| NCBI Protein Information: | CREB-regulated transcription coactivator 2 |
| UniProt Protein Name: | CREB-regulated transcription coactivator 2 |
| UniProt Synonym Protein Names: | Transducer of regulated cAMP response element-binding protein 2; TORC-2; Transducer of CREB protein 2 |
| Protein Family: | CREB-regulated transcription coactivator |
| UniProt Gene Name: | CRTC2 |
| UniProt Entry Name: | CRTC2_HUMAN |