Anti-CR1 Antibody (RACO0435)
- SKU:
- RACO0435
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 商品名: | CR1 Antibody |
| Product SKU: | RACO0435 |
| サイズ: | 50ul |
| 宿主種: | Homo sapiens (Human) |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | IHC:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | A synthesized peptide derived from human CD35 |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | Mediates cellular binding of particles and immune complexes that have activated complement. |
| シノニム: | Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35), CR1, C3BR |
 | IHC image of RACO0435 diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
 | IHC image of RACO0435 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| UniProt Protein Function: | CR1: Mediates cellular binding of particles and immune complexes that have activated complement. Belongs to the receptors of complement activation (RCA) family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q32 Cellular Component: cell surface; integral to plasma membrane; plasma membrane Molecular Function:complement component C3b receptor activity; complement component C4b binding; complement component C4b receptor activity; complement component C3b binding Biological Process: negative regulation of complement activation, alternative pathway; complement receptor mediated signaling pathway; negative regulation of complement activation, classical pathway; regulation of complement activation; innate immune response; complement activation, classical pathway Disease: Knops Blood Group System; Malaria, Susceptibility To |
| NCBI Summary: | This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17927 |
| NCBI GenInfo Identifier: | 86793036 |
| NCBI Gene ID: | 1378 |
| NCBI Accession: | NP_000564.2 |
| UniProt Secondary Accession: | P17927,Q16744, Q16745, Q5SR43, Q5SR45, Q9UQV2, |
| UniProt Related Accession: | P17927 |
| Molecular Weight: | 223,663 Da |
| NCBI Full Name: | complement receptor type 1 isoform F |
| NCBI Synonym Full Names: | complement component (3b/4b) receptor 1 (Knops blood group) |
| NCBI Official Symbol: | CR1 |
| NCBI Official Synonym Symbols: | KN; C3BR; C4BR; CD35 |
| NCBI Protein Information: | complement receptor type 1 |
| UniProt Protein Name: | Complement receptor type 1 |
| UniProt Synonym Protein Names: | C3b/C4b receptor; CD_antigen: CD35 |
| Protein Family: | Complement receptor |
| UniProt Gene Name: | CR1 |
| UniProt Entry Name: | CR1_HUMAN |