Anti-COG1 Antibody (CAB17594)
- SKU:
- CAB17594
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-COG1 Antibody |
| 抗体コード: | CAB17594 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of Human COG1. |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 22Rv1 |
| 免疫原: | A synthetic peptide of Human COG1. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 9382 |
| Uniprot: | Q8WTW3 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 109kDa |
 | Western blot - COG1 Rabbit pAb (CAB17594) |
| 同義語: | CDG2G, LDLB, COG1 |
| バックグラウンド: | The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | COG1: Required for normal Golgi function. Defects in COG1 are the cause of congenital disorder of glycosylation type 2G (CDG2G); also known as CDG-II caused by COG1 deficiency. CDGs are a family of severe inherited diseases caused by a defect in glycoprotein biosynthesis. They are characterized by under-glycosylated serum glycoproteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Clinical features of CDG2G include failure to thrive, generalized hypotonia, growth retardation and mild psychomotor retardation. CDG2G is biochemically characterized by a defect in O-glycosylation as well as N-glycosylation. Belongs to the COG1 family. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 17q25.1 Cellular Component: Golgi apparatus; Golgi membrane; Golgi transport complex; trans-Golgi network membrane Molecular Function:protein binding Biological Process: ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; retrograde transport, vesicle recycling within Golgi Disease: Congenital Disorder Of Glycosylation, Type Iig |
| NCBI Summary: | The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8WTW3 |
| NCBI GenInfo Identifier: | 22653695 |
| NCBI Gene ID: | 9382 |
| NCBI Accession: | Q8WTW3.1 |
| UniProt Secondary Accession: | Q8WTW3,Q9NPV9, Q9P2G6, |
| UniProt Related Accession: | Q8WTW3 |
| Molecular Weight: | 108,978 Da |
| NCBI Full Name: | Conserved oligomeric Golgi complex subunit 1 |
| NCBI Synonym Full Names: | component of oligomeric golgi complex 1 |
| NCBI Official Symbol: | COG1 |
| NCBI Official Synonym Symbols: | LDLB; CDG2G |
| NCBI Protein Information: | conserved oligomeric Golgi complex subunit 1 |
| UniProt Protein Name: | Conserved oligomeric Golgi complex subunit 1 |
| UniProt Synonym Protein Names: | Component of oligomeric Golgi complex 1 |
| Protein Family: | Conserved oligomeric Golgi complex |
| UniProt Gene Name: | COG1 |
| UniProt Entry Name: | COG1_HUMAN |