Anti-CLIP1 Antibody (CAB12498)
- SKU:
- CAB12498
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-CLIP1 Antibody |
| 抗体コード: | CAB12498 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1228-1427 of human CLIP1 (NP_002947.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, Mouse heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1228-1427 of human CLIP1 (NP_002947.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SALL TEKD AELE KLRN EVTV LRGE NASA KSLH SVVQ TLES DKVK LELK VKNL ELQL KENK RQLS SSSG NTDT QADE DERA QESQ IDFL NSVI VDLQ RKNQ DLKM KVEM MSEA ALNG NGDD LNNY DSDD QEKQ SKKK PRLF CDIC DCFD LHDT EDCP TQAQ MSED PPHS THHG SRGE ERPY CEIC EMFG HWAT NCND DETF |
| 遺伝子ID: | 6249 |
| Uniprot: | P30622 |
| セルラーロケーション: | Cell projection, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle membrane, Peripheral membrane protein, cytoskeleton, ruffle |
| 計算された分子量: | 156kDa/160kDa/162kDa |
| 観察された分子量: | 182kDa |
| 同義語: | CLIP1, CLIP, CLIP-170, CLIP170, CYLN1, RSN |
| バックグラウンド: | The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Restin: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Interacts with MTOR; phosphorylates and regulates CLIP1. Interacts (via CAP-Gly domains) with tubulin. Interacts with SLAIN2. Interacts (via zinc finger) with DCTN1. Interacts with MAPRE1 and MAPRE3. Detected in dendritic cells. Highly expressed in the Reed-Sternberg cells of Hodgkin disease. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 12q24.3 Cellular Component: kinetochore; microtubule cytoskeleton; ruffle; microtubule; centrosome; cytoplasmic vesicle membrane; cytoplasmic microtubule; cytoplasm; intermediate filament; cytosol; endosome Molecular Function:tubulin binding; microtubule plus-end binding; protein binding; protein homodimerization activity; nucleic acid binding; zinc ion binding; microtubule binding; metal ion binding Biological Process: mitosis; positive regulation of microtubule polymerization; mitotic cell cycle; microtubule bundle formation |
| NCBI Summary: | The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | P30622 |
| NCBI GenInfo Identifier: | 261260059 |
| NCBI Gene ID: | 6249 |
| NCBI Accession: | P30622.2 |
| UniProt Secondary Accession: | P30622,Q17RS4, Q29RG0, A0AVD3, |
| UniProt Related Accession: | P30622 |
| Molecular Weight: | 156,781 Da |
| NCBI Full Name: | CAP-Gly domain-containing linker protein 1 |
| NCBI Synonym Full Names: | CAP-GLY domain containing linker protein 1 |
| NCBI Official Symbol: | CLIP1 |
| NCBI Official Synonym Symbols: | RSN; CLIP; CYLN1; CLIP170; CLIP-170 |
| NCBI Protein Information: | CAP-Gly domain-containing linker protein 1; cytoplasmic linker protein 1; cytoplasmic linker protein CLIP-170; cytoplasmic linker protein 170 alpha-2; restin (Reed-Steinberg cell-expressed intermediate filament-associated protein) |
| UniProt Protein Name: | CAP-Gly domain-containing linker protein 1 |
| UniProt Synonym Protein Names: | Cytoplasmic linker protein 1; Cytoplasmic linker protein 170 alpha-2; CLIP-170; Reed-Sternberg intermediate filament-associated protein; Restin |
| Protein Family: | CAP-Gly domain-containing linker protein |
| UniProt Gene Name: | CLIP1 |
| UniProt Entry Name: | CLIP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLIP1 antibody (CAB12498) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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