Anti-CLDN4 Antibody (RACO0210)
- SKU:
- RACO0210
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 商品名: | CLDN4 Antibody |
| Product SKU: | RACO0210 |
| サイズ: | 50ul |
| 宿主種: | Human |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | A synthesized peptide derived from human CLDN4 |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. |
| シノニム: | Claudin-4, Clostridium perfringens enterotoxin receptor, CLDN4, CPER, CPETR1, WBSCR8 |
| UniProt Protein Function: | Claudin-4: Plays a major role in tight junction-specific obliteration of the intercellular space. CLDN4 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the claudin family. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: integral to plasma membrane; plasma membrane; tight junction Molecular Function:identical protein binding; transmembrane receptor activity Biological Process: calcium-independent cell-cell adhesion |
| NCBI Summary: | The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013] |
| UniProt Code: | O14493 |
| NCBI GenInfo Identifier: | 6685272 |
| NCBI Gene ID: | 1364 |
| NCBI Accession: | O14493.1 |
| UniProt Related Accession: | O14493 |
| Molecular Weight: | 22,077 Da |
| NCBI Full Name: | Claudin-4 |
| NCBI Synonym Full Names: | claudin 4 |
| NCBI Official Symbol: | CLDN4 |
| NCBI Official Synonym Symbols: | CPER; CPE-R; CPETR; CPETR1; WBSCR8; hCPE-R |
| NCBI Protein Information: | claudin-4 |
| UniProt Protein Name: | Claudin-4 |
| UniProt Synonym Protein Names: | Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein |
| Protein Family: | Claudin |
| UniProt Gene Name: | CLDN4 |
| UniProt Entry Name: | CLD4_HUMAN |