Anti-CLDN12 Antibody (CAB10709)
- SKU:
- CAB10709
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-CLDN12 Antibody |
| 抗体コード: | CAB10709 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN12 (NP_001172001.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN12 (NP_001172001.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGCR DVHA ATVL SFLC GIAS VAGL FAGT LLPN WRKL RLIT FNRN EKNL TVYT GLWV KCAR YDGS SDCL MYDT TWYS SVDQ LDLR VLQF ALPL SMLI AMGA |
| 遺伝子ID: | 9069 |
| Uniprot: | P56749 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, tight junction |
| 計算された分子量: | 27kDa |
| 観察された分子量: | Refer to Figures |
| 同義語: | CLDN12 |
| バックグラウンド: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found. |
| UniProt Protein Function: | Claudin-12: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Belongs to the claudin family. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 7q21.13 Cellular Component: plasma membrane; tight junction Molecular Function:identical protein binding; protein binding Biological Process: calcium-independent cell-cell adhesion |
| NCBI Summary: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011] |
| UniProt Code: | P56749 |
| NCBI GenInfo Identifier: | 6685308 |
| NCBI Gene ID: | 9069 |
| NCBI Accession: | P56749.1 |
| UniProt Secondary Accession: | P56749,Q7LDZ0, D6W5Q4, |
| UniProt Related Accession: | P56749 |
| Molecular Weight: | 27kDa |
| NCBI Full Name: | Claudin-12 |
| NCBI Synonym Full Names: | claudin 12 |
| NCBI Official Symbol: | CLDN12 |
| NCBI Protein Information: | claudin-12 |
| UniProt Protein Name: | Claudin-12 |
| Protein Family: | Claudin |
| UniProt Gene Name: | CLDN12 |
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