Anti-Claudin-8 Antibody (CAB8174)
- SKU:
- CAB8174
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | CLDN8 Rabbit Polyclonal Antibody |
| 抗体コード: | CAB8174 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-81 of human CLDN8 (NP_955360.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse lung, Mouse kidney, Mouse pancreas, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-81 of human CLDN8 (NP_955360.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QWRV SAFI ENNI VVFE NFWE GLWM NCVR QANI RMQC KIYD SLLA LSPD LQAA R |
| 遺伝子ID: | 9073 |
| Uniprot: | P56748 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, tight junction |
| 計算された分子量: | 24kDa |
| 観察された分子量: | 28kDa |
| 同義語: | CLDN8, HEL-S-79, claudin-8 |
| バックグラウンド: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. |
| UniProt Protein Function: | Claudin-8: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: endoplasmic reticulum; plasma membrane; tight junction Molecular Function:identical protein binding; protein binding Biological Process: calcium-independent cell-cell adhesion |
| NCBI Summary: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010] |
| UniProt Code: | P56748 |
| NCBI GenInfo Identifier: | 6685307 |
| NCBI Gene ID: | 9073 |
| NCBI Accession: | P56748.1 |
| UniProt Secondary Accession: | P56748,Q53EX7, D3DSE3, |
| UniProt Related Accession: | P56748 |
| Molecular Weight: | 24,845 Da |
| NCBI Full Name: | Claudin-8 |
| NCBI Synonym Full Names: | claudin 8 |
| NCBI Official Symbol: | CLDN8 |
| NCBI Official Synonym Symbols: | HEL-S-79 |
| NCBI Protein Information: | claudin-8 |
| UniProt Protein Name: | Claudin-8 |
| Protein Family: | Claudin |
| UniProt Gene Name: | CLDN8 |
| UniProt Entry Name: | CLD8_HUMAN |
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