Anti-CD70 Antibody (CAB2032)
- SKU:
- CAB2032
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CD70 Antibody |
| 抗体コード: | CAB2032 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 39-193 of human CD70 (NP_001243.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HL-60, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 39-193 of human CD70 (NP_001243.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QRFA QAQQ QLPL ESLG WDVA ELQL NHTG PQQD PRLY WQGG PALG RSFL HGPE LDKG QLRI HRDG IYMV HIQV TLAI CSST TASR HHPT TLAV GICS PASR SISL LRLS FHQG CTIA SQRL TPLA RGDT LCTN LTGT LLPS RNTD ETFF GVQW VRP |
| 遺伝子ID: | 970 |
| Uniprot: | P32970 |
| セルラーロケーション: | Membrane, Single-pass type II membrane protein |
| 計算された分子量: | 21kDa/23kDa |
| 観察された分子量: | 23kDa |
| 同義語: | CD70, CD27-L, CD27L, CD27LG, TNFSF7, TNLG8A |
| バックグラウンド: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. |
| UniProt Protein Function: | CD70: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. Belongs to the tumor necrosis factor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cytokine Chromosomal Location of Human Ortholog: 19p13 Cellular Component: extracellular space; integral to plasma membrane; plasma membrane Molecular Function:protein binding; protease binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding Biological Process: cell proliferation; cell-cell signaling; immune response; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32970 |
| NCBI GenInfo Identifier: | 21431837 |
| NCBI Gene ID: | 970 |
| NCBI Accession: | P32970.2 |
| UniProt Secondary Accession: | P32970,Q53XX4, Q96J57, B4DPR8, |
| UniProt Related Accession: | P32970 |
| Molecular Weight: | 193 |
| NCBI Full Name: | CD70 antigen |
| NCBI Synonym Full Names: | CD70 molecule |
| NCBI Official Symbol: | CD70 |
| NCBI Official Synonym Symbols: | CD27L; CD27LG; TNFSF7 |
| NCBI Protein Information: | CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7 |
| UniProt Protein Name: | CD70 antigen |
| UniProt Synonym Protein Names: | CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD_antigen: CD70 |
| Protein Family: | CD70 antigen |
| UniProt Gene Name: | CD70 |
| UniProt Entry Name: | CD70_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CD70 antibody (CAB2032) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human spleen using CD70 Rabbit pAb (CAB2032) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of Jurkat cells using CD70 Rabbit pAb (CAB2032) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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