Anti-CD3 zeta Antibody (CAB11157)
- SKU:
- CAB11157
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-CD3 zeta Antibody |
| 抗体コード: | CAB11157 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human CD3 zeta |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: | Jurkat |
| 免疫原: | A synthesized peptide derived from human CD3 zeta |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 919 |
| Uniprot: | P20963 |
| セルラーロケーション: | |
| 計算された分子量: | kDa |
| 観察された分子量: | 16KDa |
 | Western blot - CD3 zeta Rabbit mAb (CAB11157) |
| 同義語: | CD3-ZETA, CD3H, CD3Q, CD3Z, IMD25, T3Z, TCRZ |
| バックグラウンド: | The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | CD3Z: a T cell surface glycoprotein that is a component of the T cell antigen receptor. Plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD3-epsilon results in impaired immune response. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q24.2 Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; integral to membrane; alpha-beta T cell receptor complex Molecular Function:identical protein binding; protein binding; protein homodimerization activity; transmembrane receptor activity Biological Process: regulation of immune response; viral reproduction; T cell costimulation; innate immune response; T cell receptor signaling pathway; regulation of defense response to virus by virus Disease: Immunodeficiency 25 |
| NCBI Summary: | The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P20963 |
| NCBI GenInfo Identifier: | 4557431 |
| NCBI Gene ID: | 919 |
| NCBI Accession: | NP_000725.1 |
| UniProt Secondary Accession: | P20963,Q5VX13, Q8TAX4, B1AK49, |
| UniProt Related Accession: | P20963,A46461 |
| Molecular Weight: | 18,696 Da |
| NCBI Full Name: | T-cell surface glycoprotein CD3 zeta chain isoform 2 |
| NCBI Synonym Full Names: | CD247 molecule |
| NCBI Official Symbol: | CD247 |
| NCBI Official Synonym Symbols: | T3Z; CD3H; CD3Q; CD3Z; TCRZ; CD3-ZETA |
| NCBI Protein Information: | T-cell surface glycoprotein CD3 zeta chain; CD3zeta chain; TCR zeta chain; CD247 antigen, zeta subunit; T-cell receptor T3 zeta chain; CD3Z antigen, zeta polypeptide (TiT3 complex); T-cell antigen receptor complex, zeta subunit of CD3 |
| UniProt Protein Name: | T-cell surface glycoprotein CD3 zeta chain |
| UniProt Synonym Protein Names: | T-cell receptor T3 zeta chain |
| UniProt Gene Name: | CD247 |
| UniProt Entry Name: | CD3Z_HUMAN |