Anti-CD27 Antibody (RACO0475)
- SKU:
- RACO0475
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 商品名: | CD27 Antibody |
| Product SKU: | RACO0475 |
| サイズ: | 50ul |
| 宿主種: | Homo sapiens (Human) |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | WB:1:500-1:5000 |
| 反応性: | Human |
| 免疫原: | A synthesized peptide derived from human CD27 |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. |
| シノニム: | CD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (T14) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27), CD27, TNFRSF7 |
 | Western Blot. Positive WB detected in Daudi whole cell lysate HL-60 whole cell lysate THP-1 cell lysate K562 cell lysate All lanes CD27 antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 30 kDa. Observed band size: 55 kDa. |
| UniProt Protein Function: | CD27: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Apoptosis; Receptor, cytokine Chromosomal Location of Human Ortholog: 12p13 Cellular Component: integral to plasma membrane; neuron projection; nucleus; plasma membrane Molecular Function:caspase inhibitor activity; protein binding; tumor necrosis factor receptor activity Biological Process: brain development; immune response; induction of apoptosis via death domain receptors; inflammatory response; negative regulation of apoptosis; positive regulation of JNK cascade; positive regulation of MAPKKK cascade; regulation of cell proliferation; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway Disease: Lymphoproliferative Syndrome 2 |
| NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P26842 |
| NCBI GenInfo Identifier: | 269849546 |
| NCBI Gene ID: | 939 |
| NCBI Accession: | P26842.2 |
| UniProt Secondary Accession: | P26842,B2RDZ0, |
| UniProt Related Accession: | P26842 |
| Molecular Weight: | 29,137 Da |
| NCBI Full Name: | CD27 antigen |
| NCBI Synonym Full Names: | CD27 molecule |
| NCBI Official Symbol: | CD27 |
| NCBI Official Synonym Symbols: | T14; S152; Tp55; TNFRSF7; S152. LPFS2 |
| NCBI Protein Information: | CD27 antigen |
| UniProt Protein Name: | CD27 antigen |
| UniProt Synonym Protein Names: | CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7; CD_antigen: CD27 |
| Protein Family: | CD27 antigen |
| UniProt Gene Name: | CD27 |
| UniProt Entry Name: | CD27_HUMAN |