Anti-CD24 Antibody (CAB2207)
- SKU:
- CAB2207
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-CD24 Antibody |
| 抗体コード: | CAB2207 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CD24 (NP_037362.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | B cells, MCF7, SKOV3, Jurkat, Raji, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CD24 (NP_037362.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGRA MVAR LGLG LLLL ALLL PTQI YSSE TTTG TSSN SSQS TSNS GLAP NPTN ATTK AAGG ALQS TASL FVVS LSLL HLYS |
| 遺伝子ID: | 100133941 |
| Uniprot: | P25063 |
| セルラーロケーション: | Cell membrane, GPI-anchor, Lipid-anchor |
| 計算された分子量: | 8kDa |
| 観察された分子量: | 45kDa/70kDa |
| 同義語: | CD24, CD24A, CD24 molecule, CD247 |
| バックグラウンド: | This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CD24: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS). A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface. Belongs to the CD24 family. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Cell surface; Cell development/differentiation; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 6q21 Cellular Component: cell surface; membrane; plasma membrane; lipid raft Molecular Function:protein binding; signal transducer activity; protein tyrosine kinase activator activity; protein kinase binding Biological Process: respiratory burst; axon guidance; cell migration; Wnt receptor signaling pathway; regulation of phosphorylation; B cell receptor transport into lipid raft; immune response-regulating cell surface receptor signaling pathway; chemokine receptor transport out of lipid raft; positive regulation of activated T cell proliferation; positive regulation of MAP kinase activity; cell activation; cholesterol homeostasis; cell-cell adhesion; elevation of cytosolic calcium ion concentration; response to estrogen stimulus; response to molecule of bacterial origin; regulation of MAPKKK cascade; negative regulation of transforming growth factor-beta3 production; T cell costimulation; regulation of epithelial cell differentiation; response to hypoxia; regulation of cytokine and chemokine mediated signaling pathway Disease: Multiple Sclerosis, Susceptibility To |
| UniProt Code: | P25063 |
| NCBI GenInfo Identifier: | 143811372 |
| NCBI Gene ID: | |
| NCBI Accession: | P25063.2 |
| Molecular Weight: | |
| NCBI Full Name: | Signal transducer CD24 |
| UniProt Protein Name: | Signal transducer CD24 |
| UniProt Synonym Protein Names: | Small cell lung carcinoma cluster 4 antigen; CD_antigen: CD24 |
| Protein Family: | Signal transducer |
| UniProt Gene Name: | CD24 |
| UniProt Entry Name: | CD24_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CD24 antibody (CAB2207) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded mouse spleen using CD24 Rabbit pAb (CAB2207) at dilution of 1:100 (40x lens). |