Anti-CADPS2 Antibody (CAB13821)

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SKU:
CAB13821
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
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Description

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抗体名:Anti-CADPS2 Antibody
抗体コード:CAB13821
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CADPS2 (NP_001009571.2).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
ポジティブサンプル:U-87MG, A-431, SGC-7901
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CADPS2 (NP_001009571.2).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MLDP SSSE EESD EGLE EESR DVLV AAGS SQRA PPAP TREG RRDA PGRA GGGG AARS VSPS PSVL SEGR DEPQ RQLD DEQE
遺伝子ID:93664
Uniprot:Q86UW7
セルラーロケーション:Cell junction, Cytoplasmic side, Cytoplasmic vesicle membrane, Peripheral membrane protein, synapse
計算された分子量:142kDa/143kDa/147kDa
観察された分子量:148kDa
同義語:CADPS2, CAPS2
バックグラウンド:This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:CADPS2: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 7q31.3

Cellular Component: presynaptic membrane; postsynaptic membrane; cytoplasmic vesicle membrane; cell junction

Molecular Function:metal ion binding; lipid binding

Biological Process: protein transport; cellular response to starvation; synaptic vesicle priming; positive regulation of exocytosis

NCBI Summary:This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
UniProt Code:Q86UW7
NCBI GenInfo Identifier:148839294
NCBI Gene ID:93664
NCBI Accession:NP_060424
UniProt Related Accession:Q86UW7
Molecular Weight:
NCBI Full Name:calcium-dependent secretion activator 2 isoform a
NCBI Synonym Full Names:calcium dependent secretion activator 2
NCBI Official Symbol:CADPS2  
NCBI Official Synonym Symbols:CAPS2  
NCBI Protein Information:calcium-dependent secretion activator 2
UniProt Protein Name:Calcium-dependent secretion activator 2
UniProt Synonym Protein Names:Calcium-dependent activator protein for secretion 2; CAPS-2
Protein Family:Calcyphosin
UniProt Gene Name:CADPS2  
UniProt Entry Name:CAPS2_HUMAN
Anti-CADPS2 Antibody (CAB13821)Western blot analysis of extracts of various cell lines, using CADPS2 antibody (CAB13821) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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