Anti-CACNA2D3 Antibody (CAB10315)
- SKU:
- CAB10315
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CACNA2D3 Antibody |
| 抗体コード: | CAB10315 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 900-1040 of human CACNA2D3 (NP_060868.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, HeLa, HepG2, Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 900-1040 of human CACNA2D3 (NP_060868.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LYDY QAMC RANK ESSD GAHG LLDP YNAF LSAV KWIM TELV LFLV EFNL CSWW HSDM TAKA QKLK QTLE PCDT EYPA FVSE RTIK ETTG NIAC EDCS KSFV IQQI PSSN LFMV VVDS SCLC ESVA PITM APIE IRYN ESLK C |
| 遺伝子ID: | 55799 |
| Uniprot: | Q8IZS8 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 59kDa/112kDa/123kDa |
| 観察された分子量: | 123kDa |
| 同義語: | CACNA2D3, HSA272268 |
| バックグラウンド: | This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. |
| UniProt Protein Function: | CACNA2D3: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G). Belongs to the calcium channel subunit alpha-2/delta family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: plasma membrane; voltage-gated calcium channel complex Molecular Function:calcium channel activity; calcium channel regulator activity; metal ion binding; voltage-gated ion channel activity Biological Process: regulation of calcium ion transport |
| NCBI Summary: | This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8IZS8 |
| NCBI GenInfo Identifier: | 74723683 |
| NCBI Gene ID: | 55799 |
| NCBI Accession: | Q8IZS8.1 |
| UniProt Secondary Accession: | Q8IZS8,Q9NY16, Q9NY18, B2RPL6, |
| UniProt Related Accession: | Q8IZS8 |
| Molecular Weight: | 59,527 Da |
| NCBI Full Name: | Voltage-dependent calcium channel subunit alpha-2/delta-3 |
| NCBI Synonym Full Names: | calcium voltage-gated channel auxiliary subunit alpha2delta 3 |
| NCBI Official Symbol: | CACNA2D3 |
| NCBI Official Synonym Symbols: | HSA272268 |
| NCBI Protein Information: | voltage-dependent calcium channel subunit alpha-2/delta-3 |
| UniProt Protein Name: | Voltage-dependent calcium channel subunit alpha-2/delta-3 |
| UniProt Synonym Protein Names: | Voltage-gated calcium channel subunit alpha-2/delta-3 |
| Protein Family: | Voltage-dependent calcium channel |
| UniProt Gene Name: | CACNA2D3 |
| UniProt Entry Name: | CA2D3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CACNA2D3 antibody (CAB10315) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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