| UniProt Protein Function: | CABP1: Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Calcium-binding; Inhibitor; Adaptor/scaffold Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: extracellular space; internal side of plasma membrane; protein complex; postsynaptic density; dendrite; cell cortex; cytosol; Golgi membrane; postsynaptic membrane; cytoskeleton; cell soma; perinuclear region of cytoplasm; plasma membrane; nucleus; cell junction Molecular Function:enzyme inhibitor activity; protein domain specific binding; protein binding; protein homodimerization activity; nuclear localization sequence binding; type 3 metabotropic glutamate receptor binding; calcium ion binding; calcium-dependent protein binding Biological Process: negative regulation of catalytic activity; negative regulation of protein import into nucleus |
| NCBI Summary: | Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q9NZU7 |
| NCBI GenInfo Identifier: | 334302962 |
| NCBI Gene ID: | 9478 |
| NCBI Accession: | Q9NZU7.5 |
| UniProt Secondary Accession: | Q9NZU7,O95663, Q8N6H5, Q9NZU8, |
| UniProt Related Accession: | Q9NZU7 |
| Molecular Weight: | 8,139 Da |
| NCBI Full Name: | Calcium-binding protein 1 |
| NCBI Synonym Full Names: | calcium binding protein 1 |
| NCBI Official Symbol: | CABP1 |
| NCBI Official Synonym Symbols: | CALBRAIN; HCALB_BR |
| NCBI Protein Information: | calcium-binding protein 1; caldendrin; calcium binding protein 5 |
| UniProt Protein Name: | Calcium-binding protein 1 |
| UniProt Synonym Protein Names: | Calbrain; Caldendrin |
| Protein Family: | Calcium-binding protein |
| UniProt Gene Name: | CABP1 |
| UniProt Entry Name: | CABP1_HUMAN |
