Anti-C1GALT1C1 Antibody (CAB7590)
- SKU:
- CAB7590
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-C1GALT1C1 Antibody |
| 抗体コード: | CAB7590 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-190 of human C1GALT1C1 (NP_689905.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, Mouse liver, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-190 of human C1GALT1C1 (NP_689905.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | IGHG NRMH HHEH HHLQ APNK EDIL KISE DERM ELSK SFRV YCII LVKP KDVS LWAA VKET WTKH CDKA EFFS SENV KVFE SINM DTND MWLM MRKA YKYA FDKY RDQY NWFF LARP TTFA IIEN LKYF LLKK DPSQ PFYL GHTI KSGD LEYV GMEG GIVL S |
| 遺伝子ID: | 29071 |
| Uniprot: | Q96EU7 |
| セルラーロケーション: | Membrane, Single-pass type II membrane protein |
| 計算された分子量: | 36kDa |
| 観察された分子量: | 30kDa |
| 同義語: | C1GALT1C1, C1GALT2, C38H2-L1, COSMC, HSPC067, MST143, TNPS |
| バックグラウンド: | This gene encodes a type II transmembrane protein that is similar to the core 1 beta1, 3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1, 3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. |
| UniProt Protein Function: | C1GALT1C1: Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1). Defects in C1GALT1C1 are the cause of Tn syndrome (TNSYN). Tn syndrome is a rare autoimmune disease caused by somatic mutation in the C1GALT1C1 gene in which subpopulations of blood cells of all lineages carry an incompletely glycosylated membrane glycoprotein, i.e. the Tn antigen. Since leukocytes and platelets are affected as well as red cells, anemia, leukopenia and thrombocytopenia are features. Tn-polyagglutinability is sometimes associated with leukemia or is a preleukemic state. Belongs to the glycosyltransferase 31 family. Beta3- Gal-T subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xq24 Cellular Component: Golgi membrane; integral to membrane Molecular Function:protein binding; polypeptide N-acetylgalactosaminyltransferase activity Biological Process: platelet activation; protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; positive regulation of transferase activity; post-translational protein modification Disease: Tn Polyagglutination Syndrome |
| NCBI Summary: | This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2009] |
| UniProt Code: | Q96EU7 |
| NCBI GenInfo Identifier: | 74751849 |
| NCBI Gene ID: | 29071 |
| NCBI Accession: | Q96EU7.1 |
| UniProt Secondary Accession: | Q96EU7,Q8WWS3, Q9NZX1, A8K246, |
| UniProt Related Accession: | Q96EU7 |
| Molecular Weight: | 36,382 Da |
| NCBI Full Name: | C1GALT1-specific chaperone 1 |
| NCBI Synonym Full Names: | C1GALT1-specific chaperone 1 |
| NCBI Official Symbol: | C1GALT1C1 |
| NCBI Official Synonym Symbols: | TNPS; COSMC; MST143; C1GALT2; HSPC067; C38H2-L1 |
| NCBI Protein Information: | C1GALT1-specific chaperone 1; C1Gal-T2; C38H2-like protein 1; beta 1,3-galactosyltransferase 2; core 1 beta1,3-galactosyltransferase 2; core 1 beta3-Gal-T2; core 1 beta3-galactosyltransferase-specific molecular chaperone |
| UniProt Protein Name: | C1GALT1-specific chaperone 1 |
| UniProt Synonym Protein Names: | C38H2-like protein 1; C38H2-L1; Core 1 beta1,3-galactosyltransferase 2; C1Gal-T2; C1GalT2; Core 1 beta3-Gal-T2; Core 1 beta3-galactosyltransferase-specific molecular chaperone |
| Protein Family: | C1GALT1-specific chaperone |
| UniProt Gene Name: | C1GALT1C1 |
| UniProt Entry Name: | C1GLC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using C1GALT1C1 antibody (CAB7590) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat brain using C1GALT1C1 antibody (CAB7590) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using C1GALT1C1 antibody (CAB7590) at dilution of 1:100 (40x lens). |
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