Anti-BTC Antibody (CAB2588)
- SKU:
- CAB2588
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-BTC Antibody |
| 抗体コード: | CAB2588 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-178 of human BTC (NP_001720.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | OVCAR3, PC-3 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-178 of human BTC (NP_001720.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | DGNS TRSP ETNG LLCG DPEE NCAA TTTQ SKRK GHFS RCPK QYKH YCIK GRCR FVVA EQTP SCVC DEGY IGAR CERV DLFY LRGD RGQI LVIC LIAV MVVF IILV IGVC TCCH PLRK RRKR KKKE EEME TLGK DITP INED IEET NIA |
| 遺伝子ID: | 685 |
| Uniprot: | P35070 |
| セルラーロケーション: | Cell membrane, Secreted, Single-pass type I membrane protein, extracellular space |
| 計算された分子量: | 19kDa |
| 観察された分子量: | 20kDa |
| 同義語: | BTC |
| バックグラウンド: | This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. |
| UniProt Protein Function: | BTC: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. |
| UniProt Protein Details: | Protein type:Ligand, receptor tyrosine kinase; Cell cycle regulation; Membrane protein, integral Chromosomal Location of Human Ortholog: 4q13.3 Cellular Component: extracellular space; plasma membrane; integral to membrane; extracellular region Molecular Function:protein binding; growth factor activity; epidermal growth factor receptor binding Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of fibroblast proliferation; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of mitosis; positive regulation of cell proliferation; innate immune response; positive regulation of cell differentiation; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P35070 |
| NCBI GenInfo Identifier: | 461653 |
| NCBI Gene ID: | 685 |
| NCBI Accession: | P35070.1 |
| UniProt Secondary Accession: | P35070,Q96F48, |
| UniProt Related Accession: | P35070 |
| Molecular Weight: | 19,746 Da |
| NCBI Full Name: | Probetacellulin |
| NCBI Synonym Full Names: | betacellulin |
| NCBI Official Symbol: | BTC |
| NCBI Protein Information: | probetacellulin |
| UniProt Protein Name: | Probetacellulin |
| Protein Family: | Probetacellulin |
| UniProt Gene Name: | BTC |
| UniProt Entry Name: | BTC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BTC antibody (CAB2588) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |