Anti-BFSP1 Antibody (CAB3764)
- SKU:
- CAB3764
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-BFSP1 Antibody |
| 抗体コード: | CAB3764 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 281-540 of human BFSP1 (NP_001155177.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7, SKOV3, SW620, Mouse eye, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 281-540 of human BFSP1 (NP_001155177.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EESE SKFE SESK EVSP LTQE GAPE DVPD GGQI SKGF GKLY RKVK EKVR SPKE PETP TELY TKER HVLV TGDA NYVD PRFY VSSI TAKG GVAV SVAE DSVL YDGQ VEPS PESP KPPL ENGQ VGLQ EKED GQPI DQQP IDKE IEPD GAEL EGPE EKRE GEER DEES RRPC AMVT PGAE EPSI PEPP KPAA DQDG AEVL GTRS RSLP EKGP PKAL AYKT VEVV ESIE KIST ESIQ TYEE TAVI VETM IGKT KSDK KKSG EKSS |
| 遺伝子ID: | 631 |
| Uniprot: | Q12934 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cell cortex, cytoskeleton |
| 計算された分子量: | 58kDa/60kDa/74kDa |
| 観察された分子量: | 110kDa |
| 同義語: | BFSP1, CP115, CP94, CTRCT33, LIFL-H, filensin |
| バックグラウンド: | This gene encodes a lens-specific intermediate filament-like protein named filensin. The encoded protein is expressed in lens fiber cells after differentiation has begun. This protein functions as a component of the beaded filament which is a cytoskeletal structure found in lens fiber cells. Mutations in this gene are the cause of autosomal recessive cortical juvenile-onset cataract. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | BFSP1: Defects in BFSP1 are the cause of cataract cortical juvenile-onset (CCJO). A juvenile-onset cataract with opacities restricted to the cortex of the lens, not involving the nucleus. Belongs to the intermediate filament family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 20p12.1 Cellular Component: mitochondrion; cytoplasm; plasma membrane; intermediate filament; actin cytoskeleton Molecular Function:structural constituent of cytoskeleton; structural constituent of eye lens Biological Process: cell maturation Disease: Cataract 33 |
| NCBI Summary: | This gene encodes a lens-specific intermediate filament-like protein named filensin. The encoded protein is expressed in lens fiber cells after differentiation has begun. This protein functions as a component of the beaded filament which is a cytoskeletal structure found in lens fiber cells. Mutations in this gene are the cause of autosomal recessive cortical juvenile-onset cataract. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q12934 |
| NCBI GenInfo Identifier: | 17372543 |
| NCBI Gene ID: | 631 |
| NCBI Accession: | Q12934.3 |
| UniProt Secondary Accession: | Q12934,O43595, O76034, O95676, Q8IVZ6, Q9HBX4, F5H0G1 |
| UniProt Related Accession: | Q12934 |
| Molecular Weight: | 665 |
| NCBI Full Name: | Filensin |
| NCBI Synonym Full Names: | beaded filament structural protein 1, filensin |
| NCBI Official Symbol: | BFSP1 |
| NCBI Official Synonym Symbols: | CP94; CP115; LIFL-H; CTRCT33 |
| NCBI Protein Information: | filensin; cytoskeletal protein, 115 KD; lens intermediate filament-like heavy; lens fiber cell beaded-filament structural protein CP 115 |
| UniProt Protein Name: | Filensin |
| UniProt Synonym Protein Names: | Beaded filament structural protein 1; Lens fiber cell beaded-filament structural protein CP 115; CP115; Lens intermediate filament-like heavy; LIFL-H |
| Protein Family: | Filensin |
| UniProt Gene Name: | BFSP1 |
| UniProt Entry Name: | BFSP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BFSP1 antibody (CAB3764) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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