Anti-Bcl-W Antibody (CAB1158)

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SKU:
CAB1158
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
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Description

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抗体名:Anti-Bcl-W Antibody
抗体コード:CAB1158
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IHC
反応性:Human
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human Bcl-W (NP_001186768.1).
申し込み:WB IHC
推奨希釈:WB 1:500 - 1:2000 IHC 1:50 - 1:100
反応性:Human
ポジティブサンプル:A-549
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human Bcl-W (NP_001186768.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MATP ASAP DTRA LVAD FVGY KLRQ KGYV CGAG PGEG PAAD PLHQ AMRA AGDE FETR FRRT FSDL AAQL HVTP GSAQ QRFT QVSD ELFQ GGPN WGRL VAFF VFGA ALCA ESVN KEME PLVG QVQE WMVA YLET RLAD WIHS SGGW AEFT ALYG DGAL EEAR RLRE GNWA SVRT VLTG AVAL GALV TVGA FFAS K
遺伝子ID:599
Uniprot:Q92843
セルラーロケーション:Mitochondrion membrane, Peripheral membrane protein
計算された分子量:20kDa/37kDa
観察された分子量:20kDa
同義語:BCL2L2, BCL-W, BCL2-L-2, BCLW, PPP1R51
バックグラウンド:This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
UniProt Protein Function:Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
NCBI Summary:This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
UniProt Code:Q92843
NCBI GenInfo Identifier:296434404
NCBI Gene ID:599
NCBI Accession:Q92843.2
UniProt Secondary Accession:Q92843,Q2M3U0, Q5U0H4, A8K0F4,
UniProt Related Accession:Q92843
Molecular Weight:37,171 Da
NCBI Full Name:Bcl-2-like protein 2
NCBI Synonym Full Names:BCL2 like 2
NCBI Official Symbol:BCL2L2  
NCBI Official Synonym Symbols:BCLW; BCL-W; PPP1R51; BCL2-L-2  
NCBI Protein Information:bcl-2-like protein 2
UniProt Protein Name:Bcl-2-like protein 2
UniProt Synonym Protein Names:Apoptosis regulator Bcl-W
Protein Family:Bcl-2-like protein
UniProt Gene Name:BCL2L2  
UniProt Entry Name:B2CL2_HUMAN
Anti-Bcl-W Antibody (CAB1158)Western blot analysis of extracts of A549 cells, using Bcl-W Antibody (CAB1158) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-Bcl-W Antibody (CAB1158)Immunohistochemistry of paraffin-embedded human stomach using Bcl-W antibody (CAB1158) at dilution of 1:100 (40x lens).
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