Anti-BAIAP2L1 Antibody (CAB8238)
- SKU:
- CAB8238
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | BAIAP2L1 Rabbit Polyclonal Antibody |
| 抗体コード: | CAB8238 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 198-388 of human BAIAP2L1 (NP_061330.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HepG2, HeLa, 293T, A-549, Mouse lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 198-388 of human BAIAP2L1 (NP_061330.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | DKHC GFAN HIHY YHLQ SAEL LNSK LPRW QETC VDAI KVPE KIMN MIEE IKTP ASTP VSGT PQAS PMIE RSNV VRKD YDTL SKCS PKMP PAPS GRAY TSPL IDMF NNPA TAAP NSQR VNNS TGTS EDPS LQRS VSVA TGLN MMKK QKVK TIFP HTAG SNKT LLSF AQGD VITL LIPE EKDG WLYG EHDV SKA |
| 遺伝子ID: | 55971 |
| Uniprot: | Q9UHR4 |
| セルラーロケーション: | Cytoplasm, cytoskeleton |
| 計算された分子量: | 56kDa |
| 観察された分子量: | 57kDa |
| 同義語: | BAIAP2L1, IRTKS |
| バックグラウンド: | This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. |
| UniProt Protein Function: | IRTKS: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol; actin cytoskeleton Molecular Function:protein binding; actin binding Biological Process: regulation of insulin receptor signaling pathway; response to bacterium; positive regulation of actin filament polymerization; plasma membrane organization and biogenesis |
| NCBI Summary: | This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9UHR4 |
| NCBI GenInfo Identifier: | 32171238 |
| NCBI Gene ID: | 55971 |
| NCBI Accession: | NP_061330.2 |
| UniProt Secondary Accession: | Q9UHR4,Q75L21, Q75L22, Q96CV4, Q9H5F5, Q9Y2M8, A4D268 |
| UniProt Related Accession: | Q9UHR4 |
| Molecular Weight: | 57kd |
| NCBI Full Name: | brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 |
| NCBI Synonym Full Names: | BAI1-associated protein 2-like 1 |
| NCBI Official Symbol: | BAIAP2L1 |
| NCBI Official Synonym Symbols: | IRTKS |
| NCBI Protein Information: | brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 |
| UniProt Protein Name: | Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 |
| UniProt Synonym Protein Names: | Insulin receptor tyrosine kinase substrate |
| UniProt Gene Name: | BAIAP2L1 |
| UniProt Entry Name: | BI2L1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BAIAP2L1 antibody (CAB8238) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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