Anti-BACE1 Antibody (RACO0345)
- SKU:
- RACO0345
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 商品名: | BACE1 Antibody |
| Product SKU: | RACO0345 |
| サイズ: | 50ul |
| 宿主種: | Homo sapiens (Human) |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | WB:1:500-1:5000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | A synthesized peptide derived from human BACE1 |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. |
| シノニム: | Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2), BACE1, BACE KIAA1149 |
 | Western Blot. Positive WB detected in MCF-7 whole cell lysate Rat brain tissue, Mouse brain tissue. All lanes BACE1 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 56, 53, 52, 49, 46, 43 kDa. Observed band size: 72 kDa. |
| UniProt Protein Function: | BACE: an integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Cleaves APP at the amino terminus of the A-beta peptide sequence, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated carboxy-terminal fragment which is later release by gamma-secretase. Four splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:EC 3.4.23.46; Membrane protein, integral; Protease Chromosomal Location of Human Ortholog: 11q23.2-q23.3 Cellular Component: endoplasmic reticulum lumen; endosome; endosome membrane; Golgi apparatus; integral to plasma membrane; late endosome; multivesicular body; plasma membrane; trans-Golgi network Molecular Function:aspartic-type endopeptidase activity; beta-amyloid binding; beta-aspartyl-peptidase activity; enzyme binding; peptidase activity; protein binding Biological Process: beta-amyloid metabolic process; cellular protein metabolic process; membrane protein ectodomain proteolysis; protein catabolic process; proteolysis |
| NCBI Summary: | This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015] |
| UniProt Code: | P56817 |
| NCBI GenInfo Identifier: | 296434407 |
| NCBI Gene ID: | 23621 |
| NCBI Accession: | P56817.2 |
| UniProt Secondary Accession: | P56817,Q9BYB9, Q9BYC0, Q9BYC1, Q9UJT5, Q9ULS1, A0M8W7 B0YIU9, E9PE65, H7BXJ9, |
| UniProt Related Accession: | P56817 |
| Molecular Weight: | 42,107 Da |
| NCBI Full Name: | Beta-secretase 1 |
| NCBI Synonym Full Names: | beta-secretase 1 |
| NCBI Official Symbol: | BACE1 |
| NCBI Official Synonym Symbols: | ASP2; BACE; HSPC104 |
| NCBI Protein Information: | beta-secretase 1 |
| UniProt Protein Name: | Beta-secretase 1 |
| UniProt Synonym Protein Names: | Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2 |
| Protein Family: | Beta-secretase |
| UniProt Gene Name: | BACE1 |
| UniProt Entry Name: | BACE1_HUMAN |