Anti-ATP6V1C1 Antibody (CAB18253)
- SKU:
- CAB18253
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-ATP6V1C1 Antibody |
| 抗体コード: | CAB18253 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human ATP6V1C1. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | U-251MG, 293T, Mouse kidney |
| 免疫原: | A synthetic peptide of human ATP6V1C1. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 528 |
| Uniprot: | P21283 |
| セルラーロケーション: | |
| 計算された分子量: | 43kDa |
| 観察された分子量: | 43kDa |
 | Western blot - ATP6V1C1 Polyclonal Antibody (CAB18253) |
| 同義語: | ATP6V1C1, ATP6C, ATP6D, VATC, Vma5 |
| バックグラウンド: | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. |
| UniProt Protein Function: | ATP6V1C1: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase C subunit family. |
| UniProt Protein Details: | Protein type:Hydrolase; Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Transporter; EC 3.6.3.14 Chromosomal Location of Human Ortholog: 8q22.3 Cellular Component: apical part of cell; lysosomal membrane; plasma membrane; cytoplasmic vesicle; proton-transporting two-sector ATPase complex; cytosol Molecular Function:hydrogen-exporting ATPase activity, phosphorylative mechanism; protein binding; transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism Biological Process: interaction with host; proton transport; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; transmembrane transport |
| NCBI Summary: | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P21283 |
| NCBI GenInfo Identifier: | 401329 |
| NCBI Gene ID: | 528 |
| NCBI Accession: | P21283.4 |
| UniProt Related Accession: | P21283 |
| Molecular Weight: | |
| NCBI Full Name: | V-type proton ATPase subunit C 1 |
| NCBI Synonym Full Names: | ATPase H+ transporting V1 subunit C1 |
| NCBI Official Symbol: | ATP6V1C1 |
| NCBI Official Synonym Symbols: | VATC; Vma5; ATP6C; ATP6D |
| NCBI Protein Information: | V-type proton ATPase subunit C 1 |
| UniProt Protein Name: | V-type proton ATPase subunit C 1 |
| UniProt Synonym Protein Names: | Vacuolar proton pump subunit C 1 |
| UniProt Gene Name: | ATP6V1C1 |
| UniProt Entry Name: | VATC1_HUMAN |