Anti-ATP6AP2 Antibody (CAB6531)
- SKU:
- CAB6531
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ATP6AP2 Antibody |
| 抗体コード: | CAB6531 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 251-350 of human ATP6AP2 (NP_005756.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SW480, Mouse kidney, Mouse brain, Mouse eye, Rat brain, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 251-350 of human ATP6AP2 (NP_005756.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MYSL YGGN AVVE LVTV KSFD TSLI RKTR TILE AKQA KNPA SPYN LAYK YNFE YSVV FNMV LWIM IALA LAVI ITSY NIWN MDPG YDSI IYRM TNQK IRMD |
| 遺伝子ID: | 10159 |
| Uniprot: | O75787 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 35kDa/39kDa |
| 観察された分子量: | 48kDa |
| 同義語: | ATP6AP2, APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, HT028, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS |
| バックグラウンド: | This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. |
| UniProt Protein Function: | ATP6AP2: Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). Defects in ATP6AP2 are a cause of mental retardation X- linked with epilepsy (MRXE). MRXE is a syndromic mental retardation. Patients manifest mild to moderate mental retardation associated with epilepsy, delays in motor milestones and speech acquisition in infancy. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xp11.4 Cellular Component: neuron projection; integral to membrane; plasma membrane; external side of plasma membrane Molecular Function:protein binding; enzyme binding; receptor activity; aspartic-type endopeptidase activity Biological Process: positive regulation of transforming growth factor-beta1 production; rostrocaudal neural tube patterning; cellular protein metabolic process; regulation of MAPKKK cascade; proteolysis; angiotensin maturation; positive regulation of Wnt receptor signaling pathway; eye pigmentation Disease: Mental Retardation, X-linked, Syndromic, Hedera Type; Parkinsonism With Spasticity, X-linked |
| NCBI Summary: | This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75787 |
| NCBI GenInfo Identifier: | 66774158 |
| NCBI Gene ID: | 10159 |
| NCBI Accession: | O75787.2 |
| UniProt Secondary Accession: | O75787,Q5QTQ7, Q6T7F5, Q8NBP3, Q8NG15, Q96FV6, Q96LB5 Q9H2P8, Q9UG89, B7Z9I3, |
| UniProt Related Accession: | O75787 |
| Molecular Weight: | 350 |
| NCBI Full Name: | Renin receptor |
| NCBI Synonym Full Names: | ATPase, H+ transporting, lysosomal accessory protein 2 |
| NCBI Official Symbol: | ATP6AP2 |
| NCBI Official Synonym Symbols: | PRR; M8-9; MRXE; RENR; XMRE; XPDS; HT028; MRXSH; ELDF10; ATP6IP2; MSTP009; APT6M8-9; ATP6M8-9 |
| NCBI Protein Information: | renin receptor; N14F; prorenin receptor; V-ATPase M8.9 subunit; renin/prorenin receptor; ER-localized type I transmembrane adaptor; embryonic liver differentiation factor 10; ATPase H(+)-transporting lysosomal-interacting protein 2; ATPase, H+ transporting, lysosomal interacting protein 2; vacuolar ATP synthase membrane sector-associated protein M8-9; vacuolar proton ATP synthase membrane sector associated protein M8-9; ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8-9 |
| UniProt Protein Name: | Renin receptor |
| UniProt Synonym Protein Names: | ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; ER-localized type I transmembrane adaptor; Embryonic liver differentiation factor 10; N14F; Renin/prorenin receptor; Vacuolar ATP synthase membrane sector-associated protein M8-9; ATP6M8-9; V-ATPase M8.9 subunit |
| Protein Family: | Renin receptor |
| UniProt Gene Name: | ATP6AP2 |
| UniProt Entry Name: | RENR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ATP6AP2 antibody (CAB6531) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunofluorescence analysis of HeLa cells using ATP6AP2 antibody (CAB6531). Blue: DAPI for nuclear staining. |
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