Anti-ATOX1 Antibody (CAB6874)
- SKU:
- CAB6874
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ATOX1 Antibody |
| 抗体コード: | CAB6874 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-68 of human ATOX1 (NP_004036.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| 反応性: | Human |
| ポジティブサンプル: | SW480, K-562 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-68 of human ATOX1 (NP_004036.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MPKH EFSV DMTC GGCA EAVS RVLN KLGG VKYD IDLP NKKV CIES EHSM DTLL ATLK KTGK TVSY LGLE |
| 遺伝子ID: | 475 |
| Uniprot: | O00244 |
| セルラーロケーション: | |
| 計算された分子量: | 7kDa |
| 観察された分子量: | 12kDa |
| 同義語: | ATOX1, ATX1, HAH1 |
| バックグラウンド: | This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. |
| UniProt Protein Function: | ATOX1: Could bind and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense. Belongs to the ATX1 family. |
| UniProt Protein Details: | Protein type:Carrier Chromosomal Location of Human Ortholog: 5q32 Cellular Component: cytosol Molecular Function:metallochaperone activity; copper ion transmembrane transporter activity; copper ion binding; copper chaperone activity; copper-dependent protein binding Biological Process: response to reactive oxygen species; cellular copper ion homeostasis; response to oxidative stress; copper ion transport; intracellular copper ion transport |
| NCBI Summary: | This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00244 |
| NCBI GenInfo Identifier: | 7531045 |
| NCBI Gene ID: | 475 |
| NCBI Accession: | O00244.1 |
| UniProt Secondary Accession: | O00244,Q2M1R6, Q56AP3, A8KAJ8, D3DQI2, |
| UniProt Related Accession: | O00244 |
| Molecular Weight: | 68 |
| NCBI Full Name: | Copper transport protein ATOX1 |
| NCBI Synonym Full Names: | antioxidant 1 copper chaperone |
| NCBI Official Symbol: | ATOX1 |
| NCBI Official Synonym Symbols: | ATX1; HAH1 |
| NCBI Protein Information: | copper transport protein ATOX1; metal transport protein ATX1; ATX1 antioxidant protein 1 homolog |
| UniProt Protein Name: | Copper transport protein ATOX1 |
| UniProt Synonym Protein Names: | Metal transport protein ATX1 |
| Protein Family: | Copper transport protein |
| UniProt Gene Name: | ATOX1 |
| UniProt Entry Name: | ATOX1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ATOX1 Antibody (CAB6874) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Immunofluorescence analysis of MCF7 cells using ATOX1 antibody (CAB6874). Blue: DAPI for nuclear staining. |
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